The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats

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	The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats
	Pan, Yuqin; Lin, Wenjuan; Wang, Weiwen; Qi, Xiaoli; Wang, Donglin; Tang, Mingming
刊名	BEHAVIOURAL BRAIN RESEARCH
	2013
卷号	247 页码:232-240
关键词	Lipopolysaccharide Interleukin-10 Stress Depressive-like behavior
ISSN号	0166-4328
通讯作者	Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
产权排序	1,2
英文摘要	Although increasing evidence demonstrates that both chronic stressors and inflammatory immune activation contribute to pathophysiology and behavioral alterations associated with major depression, little is known about the interaction effect of central inflammatory immune activation and stress on depressivelike behavior. Our previous work has shown that 14-day chronic forced swim stress induces significant depressive-like behavior. The present investigation assessed whether pro-inflammatory cytokine and anti-inflammatory cytokine challenges have differential interaction effect on depressive-like behavior induced by chronic forced swim stress in rats. The pro-inflammatory and anti-inflammatory immune challenges were achieved respectively by central administration of lipopolysaccharide (LPS), a proinflammatory cytokine inducer, and interleukin-10 (IL-10), an anti-inflammatory cytokine. It was found that either central LPS treatment alone or chronic forced swim stress alone significantly induced depressive-like behavior, including reduced body weight gain, reduced saccharin preference and reduced locomotor activity. However, there was no significant synergistic or additive effect of central LPS treatment and stress on depressive-like behavior. LPS treatment did not exacerbate the depressive-like behavior induced by forced swim stress. Nevertheless, IL-10 reversed depressive-like behavior induced by forced swim stress, a finding indicating that IL-10 has antidepressant effect on behavioral depression induced by stress. The present findings provide new insight into the complexity of the immunityinflammation hypothesis of depression. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Sports psychology,Health psychology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	LIPOPOLYSACCHARIDE-INDUCED HYPOACTIVITY ; LIGHT-DARK CYCLE ; TOLERANCE DEVELOPMENT ; INTERLEUKIN-10 IL-10 ; SICKNESS BEHAVIORS ; PLASMA CYTOKINES ; PLUS-MAZE ; MICE ; BRAIN ; ENDOTOXIN
收录类别	SCI
项目简介	This research was supported by the grant (31170987,30770718) from the National Natural Science Foundation of China and the grants (KSOC2-2-03, KSOC2-YW-R-131) from the Chinese Academy of Sciences.
原文出处	http://ac.els-cdn.com/S0166432813001721/1-s2.0-S0166432813001721-main.pdf?_tid=b35de952-d907-11e4-acd0-00000aab0f6b&acdnat=1427958962_4493c842ba2206dc8363d018d6584208
语种	英语
WOS记录号	WOS:000319710500031
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10795]
专题	心理研究所_脑与认知科学国家重点实验室
作者单位	Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
推荐引用方式 GB/T 7714	Pan, Yuqin,Lin, Wenjuan,Wang, Weiwen,et al. The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2013,247:232-240.
APA	Pan, Yuqin,Lin, Wenjuan,Wang, Weiwen,Qi, Xiaoli,Wang, Donglin,&Tang, Mingming.(2013).The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats.BEHAVIOURAL BRAIN RESEARCH,247,232-240.
MLA	Pan, Yuqin,et al."The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats".BEHAVIOURAL BRAIN RESEARCH 247(2013):232-240.