Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine

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	Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine
	Ding, Xuekun 1,2; Liang, Jing1 ; Zheng, Xigeng1 ; Bai, Yunjing1 ; Liu, Zhengkui1 ; Li, Yingying1,2 ; Xing, Xiaoli1,2
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2013
卷号	702 页码:294-301
关键词	Morphine Increasing doses GluA1 MAPK signaling Striatum
ISSN号	0014-2999
通讯作者	Liang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Escalation of drug consumption is involved in the transition from drug use to addiction. Our previous study demonstrated that neuronal activation in ventral tegmental area (VTA) and substantia nigra (SN) was associated with behavioral sensitization induced by increasing doses of morphine. Here we sought to characterize the molecular mechanism underlying this behavioral sensitization. We compared mitogen-activated protein kinase (MAPK) signaling following pretreatment with either increasing doses or fixed doses of morphine before and after behavioral sensitization. We found phospho-MAPK markedly increased in ventral striatum and decreased in dorsal striatum after either pretreatment group, but no further change after sensitization induced by 10 mg/kg morphine challenge. Furthermore, we also evaluated the level of phospho-glutamate receptor 1 at serine 845 (pSer845-GluA1) and 831 (pSer831-GluA1) sites in ventral striatum and dorsal striatum. The results showed a significant increase in pSer845-GluA1/GluA1 ratio in ventral striatum but not dorsal striatum after pretreatment with increasing doses of morphine but not after fixed-dose or saline pretreatment. Importantly, pSer845-GluA1/GluA1 ratio was increased exclusively in dorsal striatum and not ventral striatum following acute morphine challenge specifically paired with increasing-dose pretreatment and not fixed-dose or saline. These findings indicate that behavioral sensitization-induced by chronic pretreatment with increasing doses of morphine might be more closely associated with the dynamic GluA1 activity in the striatum rather than the modulation of MAPK signaling. These findings also indicate that GluA1 phosphorylation may occur independent of MAPK activation. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Physiological psychology/Biological Psychology，
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	SIGNAL-TRANSDUCTION CASCADE ; SELF-ADMINISTERING MORPHINE ; AMPA RECEPTOR TRAFFICKING ; RAT NUCLEUS-ACCUMBENS ; BEHAVIORAL SENSITIZATION ; SYNAPTIC PLASTICITY ; SPINAL-CORD ; ENVIRONMENTAL CONTEXT ; REGULATED KINASE ; PROTEIN-KINASES
收录类别	SCI
项目简介	This work was supported by the National Foundation of Natural Science (30900400, 30971057 and 31271098) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
语种	英语
WOS记录号	WOS:000317153100038
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10775]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ding, Xuekun,Liang, Jing,Zheng, Xigeng,et al. Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2013,702:294-301.
APA	Ding, Xuekun.,Liang, Jing.,Zheng, Xigeng.,Bai, Yunjing.,Liu, Zhengkui.,...&Xing, Xiaoli.(2013).Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine.EUROPEAN JOURNAL OF PHARMACOLOGY,702,294-301.
MLA	Ding, Xuekun,et al."Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine".EUROPEAN JOURNAL OF PHARMACOLOGY 702(2013):294-301.