Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia

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	Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia
	Liu, Xia 1,2; Hong, Xiaohong 1; Chan, Raymond C. K.3 ; Kong, Fanzhi 1; Peng, Zhizhen 1,4; Wan, Xiaona 1,5; Wang, Changqing 1,6; Cheng, Lu 7
刊名	PSYCHIATRY RESEARCH
	2013
卷号	209 期号:3 页码:431-438
关键词	Patients with first episode schizophrenia Auditory evoked potential P50 Prepulse inhibition of startle reflex COMT CHRNA7
ISSN号	0165-1781
通讯作者	Hong, XH (reprint author), Shantou Univ, Coll Med, Mental Hlth Ctr, Shantou 515065, Peoples R China.
产权排序	3
英文摘要	The purpose of the current study was to explore the association of auditory P50 sensory gating (P50) and prepulse inhibition (PPI) of schizophrenia with polymorphisms in the CHRNA7 and COMT genes. One hundred and fourty patients with schizophrenia participated in this study. They were administered the tests P50 and PPI. Moreover, three single nucleotide polymorphisms (SNPs) (rs2337980, rs1909884 and rs883473) in CHRNA7 and three SNPs (rs4680, rs737865 and rs165599) in COMT were selected to be genotyped by polyacrylamide gel microarray techniques. P50 index showed significant reduction in S2 amplitude between wild-type and mutation groups in the COMT rs4680. S1 amplitude of mutation group in the COMT rs737865 was also lower compared to wild-type group. PPI index revealed a shorter pulse latency of mutation group in the rs4680. The suppression ratio of mutation group was lower in COMT rs165599. Negative findings were shown between comparisons in all the CHRNA7 SNPs. We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia. Futher studies with a larger number of subjects are needed to verify the present findings. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
学科主题	Medical psychology，Abnormal psychology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Psychiatry
研究领域[WOS]	Psychiatry
关键词[WOS]	PREPULSE INHIBITION DEFICITS ; P50 SUPPRESSION ; ACOUSTIC STARTLE ; CIGARETTE-SMOKING ; HUMAN BRAIN ; SENSORIMOTOR ; COMT ; METHYLTRANSFERASE ; RISK ; NORMALIZATION
收录类别	SCI
项目简介	This study was supported partially by a grant from the National "Tenth Five-year" Science and Technology Program (2002BA711A08), the National Science Fund China (81088001), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the National Basic Research Programme (973 Programme No. 2007CB512305).
原文出处	http://ac.els-cdn.com/S0165178113001583/1-s2.0-S0165178113001583-main.pdf?_tid=e6ce0d06-a84e-11e4-8cdd-00000aacb361&acdnat=1422601936_e2327042facb7754f55e51eabbeafb7a
语种	英语
WOS记录号	WOS:000326766300029
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10731]
专题	心理研究所_脑与认知科学国家重点实验室
作者单位	1.Shantou Univ, Coll Med, Mental Hlth Ctr, Shantou 515065, Peoples R China 2.Mental Hlth Hosp Jining, Jining, Peoples R China 3.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 4.Third Peoples Hosp Zhongshan, Zhongshan, Peoples R China 5.Seventh Hosp Qingdao, Qingdao, Peoples R China 6.Chron Dis Hosp Baoan Dist Shenzhen, Shenzhen, Guangdong, Peoples R China 7.Southeast Univ, Minist Educ, Key Lab Child Dev & Learning Sci, Nanjing, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xia,Hong, Xiaohong,Chan, Raymond C. K.,et al. Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia[J]. PSYCHIATRY RESEARCH,2013,209(3):431-438.
APA	Liu, Xia.,Hong, Xiaohong.,Chan, Raymond C. K..,Kong, Fanzhi.,Peng, Zhizhen.,...&Cheng, Lu.(2013).Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia.PSYCHIATRY RESEARCH,209(3),431-438.
MLA	Liu, Xia,et al."Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia".PSYCHIATRY RESEARCH 209.3(2013):431-438.