Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels

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	Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels
	Liu C(刘超); Xue CD; Chen XD(陈晓东); Shan L; Tian Y; Hu GQ(胡国庆)
刊名	Analytical Chemistry
	2015-05-19
通讯作者邮箱	guoqing.hu@imech.ac.cn
卷号	87 期号:12 页码:6041-6048
ISSN号	0003-2700
通讯作者	Hu GQ(胡国庆), State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics,Chinese Academy of Sciences, Beijing 100190, China
中文摘要	Viscoelasticity-induced particle migration has recently received increasing attention due to its ability to obtain high-quality focusing over a wide range of flow rates. However, its application is limited to low throughput regime since the particles can defocus as flow rate increases. Using an engineered carrier medium with constant and low viscosity and strong elasticity, the sample flow rates are improved to be 1 order of magnitude higher than those in existing studies. Utilizing differential focusing of particles of different sizes, here, we present sheathless particle/cell separation in simple straight microchannels that possess excellent parallelizability for further throughput enhancement. The present method can be implemented over a wide range of particle/cell sizes and flow rates. We successfully separate small particles from larger particles, MCF-7 cells from red blood cells (RBCs), and Escherichia coli (E. coli) bacteria from RBCs in different straight microchannels. The proposed method could broaden the applications of viscoelastic microfluidic devices to particle/cell separation due to the enhanced sample throughput and simple channel design.
分类号	一类
类目[WOS]	Chemistry, Analytical
研究领域[WOS]	Chemistry
关键词[WOS]	VISCOSITY ELASTIC FLUIDS ; MICROFLUIDIC CHANNEL ; FLOW FRACTIONATION ; BLOOD ; CHIP ; MIGRATION ; TECHNOLOGY ; FILTRATION ; CYLINDER ; FOCUSER
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000356755100027
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/52049]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Liu C,Xue CD,Chen XD,et al. Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels[J]. Analytical Chemistry,2015,87(12):6041-6048.
APA	Liu C,Xue CD,Chen XD,Shan L,Tian Y,&Hu GQ.(2015).Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels.Analytical Chemistry,87(12),6041-6048.
MLA	Liu C,et al."Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels".Analytical Chemistry 87.12(2015):6041-6048.