Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics

CORC > 理论物理研究所 > 中国科学院理论物理研究所 > 理论物理所科研产出 > 理论物理所1978-2010年知识产出

	Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics
	Care, BR ; Carrivain, P ; Forne, T ; Victor, JM ; Lesne, A
刊名	COMMUNICATIONS IN THEORETICAL PHYSICS
	2014
卷号	62 期号:4 页码:607-616
关键词	COIL-GLOBULE TRANSITION POLYMER-CHAIN CHROMATIN PHYSICS ORGANIZATION COLLAPSE LOCUS
ISSN号	0253-6102
通讯作者	Lesne, A (reprint author), Univ Paris 06, CNRS UMR 7600, Lab Phys Theor Mat Condensee, F-75005 Paris, France.
英文摘要	Investigating average thermodynamic quantities is not sufficient to understand conformational transitions of a finite-size polymer. We propose that such transitions are better described in terms of the probability distribution of some finite-size order parameter, and the evolution of this distribution as a control parameter varies. We demonstrate this claim for the coil-globule transition of a linear polymer and its mapping onto a two-state model. In a biological context, polymer models delineate the physical constraints experienced by the genome at different levels of organization, from DNA to chromatin to chromosome. We apply our finite-size approach to the formation of plectonemes in a DNA segment submitted to an applied torque and the ensuing helix-coil transition that can be numerically observed, with a coexistence of the helix and coil states in a range of parameters. Polymer models are also essential to analyze recent in vivo experiments providing the frequency of pairwise contacts between genomic loci. The probability distribution of these contacts yields quantitative information on the conformational fluctuations of chromosome regions. The changes observed in the shape of the distribution when the cell type or the physiological conditions vary may reveal an epigenetic modulation of the conformational constraints experienced by the chromosomes.
学科主题	Physics
收录类别	SCI
资助信息	French Institut de la Recherche Medicale [MICROMEGAS PC201104]; French Institut National du Cancer [INCa-5960]; French Agence Nationale de la Recherche [ANR-13-BSV5-0010-03]
语种	英语
WOS记录号	WOS:000345826400018
公开日期	2015-06-03
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/15640]
专题	理论物理研究所_理论物理所1978-2010年知识产出
推荐引用方式 GB/T 7714	Care, BR,Carrivain, P,Forne, T,et al. Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2014,62(4):607-616.
APA	Care, BR,Carrivain, P,Forne, T,Victor, JM,&Lesne, A.(2014).Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics.COMMUNICATIONS IN THEORETICAL PHYSICS,62(4),607-616.
MLA	Care, BR,et al."Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics".COMMUNICATIONS IN THEORETICAL PHYSICS 62.4(2014):607-616.