SMYD Proteins: Key Regulators in Skeletal and Cardiac Muscle Development and Function

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	SMYD Proteins: Key Regulators in Skeletal and Cardiac Muscle Development and Function
	Du, Shao Jun 1; Tan, Xungang2 ; Zhang, Jianshe 3
刊名	ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
	2014-09-01
卷号	297 期号:9 页码:1650-1662
关键词	Smyd1 Smyd2 Hsp90 Unc45b myofibrillogenesis sarcomere
通讯作者	Du, SJ (reprint author), Univ Maryland, Sch Med, Dept Biochem & Mol Biol, 701 E Pratt St, Baltimore, MD 21202 USA.
英文摘要	Muscle fibers are composed of myofibrils, one of the most highly ordered macromolecular assemblies in cells. Recent studies demonstrate that members of the Smyd family play critical roles in myofibril assembly of skeletal and cardiac muscle during development. The Smyd family consists of five members including Smyd1, Smyd2, Smyd3, Smyd4, and Smyd5. They share two highly conserved structural and functional domains, namely the SET and MYND domains involved in lysine methylation and protein-protein interaction, respectively. Smyd1 is specifically expressed in muscle cells under the regulation of myogenic transcriptional factors of the MyoD and Mef2 families and the serum responsive factor. Loss of function studies reveal that Smyd1 is required for cardio-myogenesis and sarcomere assembly in skeletal and cardiac muscles. Smyd2, on another hand, is dispensable for heart development in mice. However, Smyd2 appears to play a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in the development or function of adult muscle. The molecular mechanisms by which Smyd family proteins function in muscle cells are not well understood. It has been suggested that members of the Smyd family may use multiple mechanisms to control muscle development and cell differentiation, including transcriptional regulation, epigenetic regulation via histone methylation, and methylation of proteins other than histones, such as molecular chaperone Hsp90. (C) 2014 Wiley Periodicals, Inc.
学科主题	Anatomy & Morphology
收录类别	SCI
语种	英语
WOS记录号	WOS:000340678300013
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/24168]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21202 USA 2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 3.Changsha Univ, Dept Bioengn & Environm Sci, Changsha, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Du, Shao Jun,Tan, Xungang,Zhang, Jianshe. SMYD Proteins: Key Regulators in Skeletal and Cardiac Muscle Development and Function[J]. ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY,2014,297(9):1650-1662.
APA	Du, Shao Jun,Tan, Xungang,&Zhang, Jianshe.(2014).SMYD Proteins: Key Regulators in Skeletal and Cardiac Muscle Development and Function.ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY,297(9),1650-1662.
MLA	Du, Shao Jun,et al."SMYD Proteins: Key Regulators in Skeletal and Cardiac Muscle Development and Function".ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY 297.9(2014):1650-1662.