In depth analysis of the in vivo toxicity of venom from the jellyfish Stomolophus meleagris

	In depth analysis of the in vivo toxicity of venom from the jellyfish Stomolophus meleagris
	Li, Rongfeng 1; Yu, Huahua1 ; Yue, Yang1,2 ; Liu, Song 1; Xing, Ronge1 ; Chen, Xiaolin 1; Wang, Xueqin 1,2; Li, Pengcheng1
刊名	TOXICON
	2014-12-15
卷号	92 页码:60-65
关键词	Jellyfish Stomolophus meleagris Nemopilema nomurai Venom Sting
通讯作者	Li, PC (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
英文摘要	Jellyfish Stomolophus meleagris, a synonym of Nemopilema nomurai, which has often bloomed in the China Sea in recent years, is becoming an increasing threat to human health and life as a result of its strong toxicity. Each year, hundreds of thousands of people were stung, especially in the high season, and the victims suffered itch, edema, myalgia, dyspnea, hypotension, shock and even death. Here, we present the in-depth analysis of the in vivo toxicity of the venom from the jellyfish S. meleagris by using both an acute toxicological approach and pathological analyses. The venom showed an LD50 of approximately 2.92 mu g/g body weight in mice following an intravenous injection and caused renal glomerular swelling, renal vesicle stricture, renal tubules dilatation, hepatic blood sinusoid dilatation, pulmonary edema and malignant pleural effusion. The pathological sections analysis showed that the kidney and liver were significantly damaged, but the heart, spleen and stomach had no observed changes. Additionally, the hemanalysis showed an increase of white blood cells (WBC), middle cells (Mid), alanine aminotransferase (ALT), blood urine nitrogen (BUN) and uric acid (UA) in the blood. Moreover, the mice also displayed convulsions, mouth bleeding, piloerection, dyspnea and death after the injection of the venom. In conclusion, this venom has a strong toxicity to the kidney of the mice and the acute renal failure might be one of the most important factors for the death after a severe sting. Hopefully, the present study will provide a significant reference for the treatment of stings by the jellyfish S. meleagris in the future. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Toxicology
收录类别	SCI
语种	英语
WOS记录号	WOS:000348014900010
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/24226]
专题	海洋研究所_海洋生物技术研发中心海洋研究所_实验海洋生物学重点实验室海洋研究所_海洋环境工程技术研究发展中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Rongfeng,Yu, Huahua,Yue, Yang,et al. In depth analysis of the in vivo toxicity of venom from the jellyfish Stomolophus meleagris[J]. TOXICON,2014,92:60-65.
APA	Li, Rongfeng.,Yu, Huahua.,Yue, Yang.,Liu, Song.,Xing, Ronge.,...&Li, Pengcheng.(2014).In depth analysis of the in vivo toxicity of venom from the jellyfish Stomolophus meleagris.TOXICON,92,60-65.
MLA	Li, Rongfeng,et al."In depth analysis of the in vivo toxicity of venom from the jellyfish Stomolophus meleagris".TOXICON 92(2014):60-65.