Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages | |
Luo, Nana1,2; Ni, Dezhi1,2; Yue, Hua1; Wei, Wei1; Ma, Guanghui1,3 | |
刊名 | ACS APPLIED MATERIALS & INTERFACES |
2015-03-11 | |
卷号 | 7期号:9页码:5239-5247 |
关键词 | graphene oxide macrophage surface engineering biological outcomes apoptosis |
ISSN号 | 1944-8244 |
通讯作者 | Wei, W (reprint author), Chinese Acad Sci, Nat Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China. |
英文摘要 | The "nano-bio" interface profoundly shapes the interaction between cells and nanomaterials and can even decide a cell's fate. As a nascent two-dimensional material, graphene has many unique attributes and is proposed to be a promising candidate for biomedical applications. Thus, for graphene-based applications, it is necessary to clarify how the graphene surface navigates biological outcomes when encountering "janitorial" cells (macrophages). For this purpose, we synthesized nanographene oxide (nGO) and engineered the surface with polyethylene glycol (PEG), bovine serum albumin (BSA), and poly(ether imide) (PEI). In contrast to pristine nGO, decoration with PEG and BSA hindered endocytosis and improved their benignancy toward macrophages. Contrarily, nGO-PEI commenced with favorable endocytosis but then suffered stagnation due to compromised macrophage viability. To unravel the underlying mechanisms regulating these diverse macrophage fates, we built a stepwise analysis. Compared to the others, nGO-PEI tended to interact electrostatically with mitochondria after their cellular internalization. Such an unexpected encounter disrupted the normal potential and integrity of mitochondria and then elicited an alteration in reactive oxygen species and cytochrome c. These responses further initiated the activation of the caspase family and ultimately dictated cells to undergo apoptosis. The advances described above will complement our knowledge of graphene functionality and serve to guide its application in biotechnological applications. |
学科主题 | Science & Technology - Other Topics ; Materials Science |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
关键词[WOS] | WALLED CARBON NANOTUBES ; NANO-GRAPHENE ; NANOPARTICLE SIZE ; DRUG-DELIVERY ; CELL-DEATH ; OXIDE ; NANOMATERIALS ; CHEMISTRY ; APOPTOSIS ; PROTEINS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000350614600026 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/13812] |
专题 | 过程工程研究所_研究所(批量导入) |
作者单位 | 1.Chinese Acad Sci, Nat Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China |
推荐引用方式 GB/T 7714 | Luo, Nana,Ni, Dezhi,Yue, Hua,et al. Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(9):5239-5247. |
APA | Luo, Nana,Ni, Dezhi,Yue, Hua,Wei, Wei,&Ma, Guanghui.(2015).Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages.ACS APPLIED MATERIALS & INTERFACES,7(9),5239-5247. |
MLA | Luo, Nana,et al."Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages".ACS APPLIED MATERIALS & INTERFACES 7.9(2015):5239-5247. |
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