Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine | |
Qiao, Weilin1,2; Ji, Shaoyang2; Zhao, Yubao1; Hu, Tao2 | |
刊名 | VACCINE |
2015-04-21 | |
卷号 | 33期号:17页码:2066-2072 |
关键词 | Meningococcal polysaccharide Conjugate vaccine beta-Glucan Adjuvant |
ISSN号 | 0264-410X |
通讯作者 | Zhao, YB (reprint author), Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China. |
英文摘要 | Meningococcal disease is a fatal illness of sudden onset caused by Neisseria meningitides. Meningococcal capsular polysaccharide (CPS) is a major virulence factor that generally does not induce immunological memory. Conjugation with a carrier protein can significantly increase the immunogenicity of CPS and induce immunological memory. However, it is highly desired to optimize the CPS-specific immunogenicity of the conjugate vaccine. Although adjuvant has been widely used to improve the immunogenicity of antigens, co-administration and conjugation of adjuvant with the conjugate vaccine has rarely been investigated. As a stimulator of humoral and cellular immunity, beta-glucan can activate macrophages and trigger intracellular processes to secrete cytokines initiating inflammatory reactions. In the present study, a conjugate vaccine (CPS-TT) was generated by conjugation of tetanus toxoid (TT) with meningococcal group Y CPS. CPS-TT was further conjugated with beta-glucan to generate CPS-TT-G. Immunization with CPS-TT-G led to an 8.2-fold increase in the CPS-specific IgG titers as compared with CPS-TT. Presumably, conjugation of beta-glucan ensured the two components to simultaneously reach the antigen presenting cells and stimulate the immune response. In contrast, co-administration of beta-glucan suppressed the CPS-specific immunogenicity of CPS-TT. Thus, conjugation of beta-glucan is an effective strategy to markedly improve the CPS-specific immunogenicity of the conjugate vaccine. (C) 2015 Elsevier Ltd. All rights reserved. |
学科主题 | Immunology ; Research & Experimental Medicine |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Immunology ; Medicine, Research & Experimental |
研究领域[WOS] | Immunology ; Research & Experimental Medicine |
关键词[WOS] | NEISSERIA-MENINGITIDIS ; SPACER ARM ; GROUP-A ; DISEASE ; ANTIGEN ; ACID ; IMMUNIZATION ; PROTECTION ; ANTIBODIES ; SEROGROUPS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000353079100011 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/13777] |
专题 | 过程工程研究所_研究所(批量导入) |
作者单位 | 1.Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Qiao, Weilin,Ji, Shaoyang,Zhao, Yubao,et al. Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine[J]. VACCINE,2015,33(17):2066-2072. |
APA | Qiao, Weilin,Ji, Shaoyang,Zhao, Yubao,&Hu, Tao.(2015).Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine.VACCINE,33(17),2066-2072. |
MLA | Qiao, Weilin,et al."Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine".VACCINE 33.17(2015):2066-2072. |
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