Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy

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	Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy
	Liu, Shi-Ying 1,2; Wei, Wei 1; Yue, Hua 1; Ni, De-Zhi 1,2; Yue, Zhan-Guo 1,2; Wang, Shuang 1,2; Fu, Qiang 1,3; Wang, Yue-Qi 1,2; Ma, Guang-Hui 1; Su, Zhi-Guo 1
刊名	BIOMATERIALS
	2013-11-01
卷号	34 期号:33 页码:8291-8300
关键词	Whole cell tumor vaccine Adjuvant Nanoparticle Cytokine
英文摘要	Whole cell tumor vaccine (WCTV), as a potential treatment modality, elicits limited immune responses because of the poor immunogenicity. To address this issue, researchers have attempted to transduce a cytokine adjuvant into tumor cells, but these single-adjuvant WCTVs curtail the high expectations. In present study, we constructed a multi-adjuvant WCTV based on the nanopartides modified with cell penetrating peptide, which could facilitate the transportation of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 2 (IL-2) into tumor cells. After inactivation, as-designed multi-adjuvant WCTV exhibited programmed promotions on DC recruitment, antigen presentation, and T-cell activation. In vivo evaluations demonstrated the satisfactory effects on tumor growth suppression, metastasis inhibition, and recurrence prevention. Therefore, the nanoparticles-based multiadjuvant WCTV may serve as a high-performance treatment for anti-tumor immunotherapy. (C) 2013 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	DENDRITIC CELLS ; CROSS-PRESENTATION ; CHEMOTHERAPY ; IMMUNITY ; MELANOMA ; TAT
收录类别	SCI
语种	英语
WOS记录号	WOS:000324720700028
公开日期	2015-05-27
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/13624]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shandong Univ, Key Lab Cell & Dev Biol, Life Sci Coll, Jinan 250100, Peoples R China
推荐引用方式 GB/T 7714	Liu, Shi-Ying,Wei, Wei,Yue, Hua,et al. Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy[J]. BIOMATERIALS,2013,34(33):8291-8300.
APA	Liu, Shi-Ying.,Wei, Wei.,Yue, Hua.,Ni, De-Zhi.,Yue, Zhan-Guo.,...&Su, Zhi-Guo.(2013).Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy.BIOMATERIALS,34(33),8291-8300.
MLA	Liu, Shi-Ying,et al."Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy".BIOMATERIALS 34.33(2013):8291-8300.