Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention

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	Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention
	Wang, Lianyan 1; Liu, Yuan 1,2; Zhang, Weifeng 1,2; Chen, Xiaoming 1,2; Yang, Tingyuan 1; Ma, Guanghui 1
刊名	CURRENT PHARMACEUTICAL DESIGN
	2013-10-01
卷号	19 期号:35 页码:6340-6352
关键词	Hydrophilic polymer microspheres hydrophobic polymer microcapsules protein delivery activity retention strategies
英文摘要	With the recent progress in biotechnology and genetic engineering, a variety of proteins have formed a very important class of therapeutic agents. However, most proteins have short half-lives in vivo requiring multiple treatments to provide efficacy. In order to overcome this limitation, sustained release systems as hydrophilic microspheres and hydrophobic microcapsules have received extensive attention in recent years. As therapeutic proteins delivery systems, it is necessary to maintain protein bioactivity during microspheres or microcapsules formation as much as possible. This paper reviews different influencing factors that are closely involved in protein denaturation during the preparation of hydrophilic polymer microspheres and hydrophobic polymer microcapsules. The various strategies usually employed for overcoming these obstacles are described in detail. Both processing and formulation parameters can be modified for improving protein stability. The maximum or full protein stability retention within the microspheres or microcapsules might be achieved by individual or combined optimized strategies. In addition, the common techniques for proteins stability determination are also briefly reviewed.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	HUMAN GROWTH-HORMONE ; ALPHA-CHYMOTRYPSIN STABILITY ; POLY-DL-LACTIDE-POLY(ETHYLENE GLYCOL) MICROSPHERES ; SUSTAINED-RELEASE FORMULATION ; POLYMERIC MULTILAYER CAPSULES ; PLGA MICROSPHERES ; CHITOSAN MICROSPHERES ; BIODEGRADABLE MICROSPHERES ; POLY(ETHYLENE GLYCOL) ; IN-VITRO
收录类别	SCI
语种	英语
WOS记录号	WOS:000324629400010
公开日期	2015-05-27
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/13549]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lianyan,Liu, Yuan,Zhang, Weifeng,et al. Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention[J]. CURRENT PHARMACEUTICAL DESIGN,2013,19(35):6340-6352.
APA	Wang, Lianyan,Liu, Yuan,Zhang, Weifeng,Chen, Xiaoming,Yang, Tingyuan,&Ma, Guanghui.(2013).Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention.CURRENT PHARMACEUTICAL DESIGN,19(35),6340-6352.
MLA	Wang, Lianyan,et al."Microspheres and Microcapsules for Protein Delivery: Strategies of Drug Activity Retention".CURRENT PHARMACEUTICAL DESIGN 19.35(2013):6340-6352.