The principle of compromise in competition: exploring stability condition of protein folding

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	The principle of compromise in competition: exploring stability condition of protein folding
	Xu, J. ; Han, M. Z. ; Ren, Y. ; Li, J. H.
刊名	Science Bulletin
	2015
期号	1 页码:76-85
关键词	Protein folding Dynamic structure Multiple mechanisms Compromise in competition Mesoscale Stability MOLECULAR-DYNAMICS SIMULATIONS COMPLEX-SYSTEMS TRANSACTIVATION DOMAIN MULTISCALE METHODOLOGY KIX DOMAIN PEPTIDE BINDING ENERGY CREB FLOW
其他题名	Sci. Bull.
中文摘要	Thermodynamic hypothesis and kinetic stability are currently used to understand protein folding. The former assumes that free energy minimum is the exclusive dominant mechanism in most cases, while the latter shows that some proteins have even lower free energy in intermediate states and their native states are kinetically trapped in the higher free energy region. This article explores the stability condition of protein structures on the basis of our study of complex chemical systems. We believe that separating one from another is not reasonable since they should be coupled, and protein structures should be dominated by at least two mechanisms resulting in different characteristic states. It is concluded that: (1) Structures of proteins are dynamic, showing multiple characteristic states emerging alternately and each dominated by a respective mechanism. (2) Compromise in competition of multiple dominant mechanisms might be the key to understanding the stability of protein structures. (3) The dynamic process of protein folding should be depicted through the time series of both its energetic and structural changes, which is much meaningful and applicable than the free energy landscape.
收录类别	SCI
原文出处	://WOS:000347924400010
语种	英语
WOS记录号	WOS:000347924400010
公开日期	2015-04-01
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/11862]
专题	过程工程研究所_研究所（批量导入）
推荐引用方式 GB/T 7714	Xu, J.,Han, M. Z.,Ren, Y.,et al. The principle of compromise in competition: exploring stability condition of protein folding[J]. Science Bulletin,2015(1):76-85.
APA	Xu, J.,Han, M. Z.,Ren, Y.,&Li, J. H..(2015).The principle of compromise in competition: exploring stability condition of protein folding.Science Bulletin(1),76-85.
MLA	Xu, J.,et al."The principle of compromise in competition: exploring stability condition of protein folding".Science Bulletin .1(2015):76-85.