Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 城市与区域生态国家重点实验室

	Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China
	Li, Jian ; Ren, Shujuan ; Han, Shaolun ; Lei, Bingli ; Li, Na
刊名	ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
	2014
卷号	67 期号:1 页码:68-77
ISSN号	0090-4341
中文摘要	Thyroid hormone (TH) has long been known to be essential for normal brain development in both humans and animals, and increasing evidence suggests that environmental components may disrupt TH signaling. In the present study, two-hybrid yeast bioassay and chemical analysis were used to evaluate and identify thyroid-receptor (TR) disruptors in water from the Guanting Reservoir, Beijing, China. Modified yeast bioassay showed that the water samples could affect TH signaling. The bioassay-derived amiodarone hydrochloride equivalents ranged from 33.8 +/- A 3.3 to 308.5 +/- A 31.8 A mu g/L. Solid-phase extraction was used to separate the organic extracts, which were subjected to bioassay and chemical analysis. The organic extracts significantly antagonized the TR, which accounted for > 86.0 % of the total effects. Thus, organic extracts may play a major role in the TR-disruption activity of the water. Phenols, organochlorine pesticides, and phthalate esters were detected in the organic extracts. Chemical analysis and toxic-equivalent calculation showed that a major cause of the TR antagonism of the water was dibutyl phthalate (80.1 to 122.7 %).
WOS记录号	WOS:000336983300008
公开日期	2015-03-23
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/9172]
专题	生态环境研究中心_城市与区域生态国家重点实验室
推荐引用方式 GB/T 7714	Li, Jian,Ren, Shujuan,Han, Shaolun,et al. Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China[J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2014,67(1):68-77.
APA	Li, Jian,Ren, Shujuan,Han, Shaolun,Lei, Bingli,&Li, Na.(2014).Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China.ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,67(1),68-77.
MLA	Li, Jian,et al."Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China".ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 67.1(2014):68-77.