DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery

	DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery
	Zhou, Li ; Chen, Zhaowei ; Dong, Kai ; Yin,Meili ; Ren,Jinsong ; Qu,Xiaogang
刊名	biomaterials
	2014
卷号	35 期号:30 页码:8694-8702
关键词	PHOSPHATE NANOCOMPOSITE PARTICLES CALCIUM-PHOSPHATE HOLLOW SPHERES GENE DELIVERY NUCLEIC-ACID CANCER-CELLS TRANSFECTION NANOPROBES OXIDE METALLIZATION
ISSN号	0142-9612
通讯作者	ren,js
中文摘要	a dna-guided method for surface engineering of nagdf4:ce/tb hybrid nanoparticle has been proposed. in this study, the dna molecules that retained after one-pot nagdf4:ce/tb synthesis is directly utilized as biotemplate for cap heterogeneous nucleation, thus the dual-purpose function of dna is realized in the current study which could afford a new type of ph-responsive theranostic platform to enhance the therapeutic efficiency while minimizing side effects. the introduction of another layer of aptamer molecules on cap facilitated cellular uptake of the resulting nanocomposite into specific target cells via receptor-mediated endocytosis. after been taken by the target tumor cells, the nagdf4:ce/tb@cap was found to be mostly accumulated in lysosome, which facilitated the dissolving of cap coatings as non-toxic ions to initiate drug release and efficient cancer cell destruction. we envision that the hybrid nanocarrier may serve as practical and multifunctional probe for cancer therapy and the presented synthesis approach here may also benefit the preparation of many other types of multifunctional inorganic-biomolecular hybrid nanostructures based on the dna nanotechnology. (c) 2014 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000340849600023
公开日期	2015-03-25
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50675]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhou, Li,Chen, Zhaowei,Dong, Kai,et al. DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery[J]. biomaterials,2014,35(30):8694-8702.
APA	Zhou, Li,Chen, Zhaowei,Dong, Kai,Yin,Meili,Ren,Jinsong,&Qu,Xiaogang.(2014).DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery.biomaterials,35(30),8694-8702.
MLA	Zhou, Li,et al."DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery".biomaterials 35.30(2014):8694-8702.