Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin

	Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin
	Li, Mingqiang ; Tang, Zhaohui ; Lv, Shixian ; Song,Wantong ; Hong,Hua ; Jing,Xiabin ; Zhang,Yuanyuan ; Chen,Xuesi
刊名	biomaterials
	2014
卷号	35 期号:12 页码:3851-3864
关键词	TARGETED DRUG-DELIVERY THERMOSENSITIVE POLYMERIC MICELLES ANTICANCER DRUGS KINETIC STABILITY CANCER-CELLS IN-VIVO CHEMOTHERAPY REDUCTION RELEASE NANOGELS
ISSN号	0142-9612
通讯作者	chen,xs
中文摘要	ph responsive cisplatin prodrug crosslinked polysaccharide-based nanoparticles were developed from succinic acid decorated dextran (dex-sa) for active loading and triggered intracellular release of doxorubicin (dox). nanoparticles with uniform size were formed spontaneously in aqueous medium via electrostatic interaction between anionic dex-sa and cationic dox, and subsequently transformed into crosslinked nanoparticles (cl-nanoparticles) in situ by readily crosslinking the micelles via chelate interactions between the ionic polymeric carrier and the platinum (ii) antitumor drug. this strategy eliminated the need of organic solvents and sophisticated processes in the drug loading procedure. the in vitro release studies showed that dox was released from the cl-nanoparticles in a controlled and ph dependent manner. furthermore, the pharmacokinetics and biodistribution investigations indicated that, as compared to the non-crosslinked nanoparticles (ncl-nanoparticles) and free dox, the clnanoparticles significantly prolonged the blood circulation time of drug, decreased accumulation in the normal tissues and enriched drug into the tumors. as a consequence, the dox-loaded cl-nanoparticles exhibited enhanced therapeutic efficacy in tumor-bearing mice compared with the ncl-nanoparticles and free dox, which were further confirmed by the histological and immunohistochemical analyses. these cisplatin prodrug crosslinked polysaccharide nanoparticles proved to be a promising nanomedicine drug delivery system for tumor-targeted delivery of dox. (c) 2014 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000332431700014
公开日期	2015-03-25
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50670]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li, Mingqiang,Tang, Zhaohui,Lv, Shixian,et al. Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin[J]. biomaterials,2014,35(12):3851-3864.
APA	Li, Mingqiang.,Tang, Zhaohui.,Lv, Shixian.,Song,Wantong.,Hong,Hua.,...&Chen,Xuesi.(2014).Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin.biomaterials,35(12),3851-3864.
MLA	Li, Mingqiang,et al."Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin".biomaterials 35.12(2014):3851-3864.