Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin

	Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin
	Song, Wantong ; Tang, Zhaohui ; Zhang, Dawei ; Zhang,Ying ; Yu,Haiyang ; Li,Mingqiang ; Lv,Shixian ; Sun,Hai ; Deng,Mingxiao ; Chen,Xuesi
刊名	biomaterials
	2014
卷号	35 期号:9 页码:3005-3014
关键词	CELL LUNG-CANCER DRUG-DELIVERY BREAST-CANCER LIPOSOMAL DOXORUBICIN MULTIDRUG-RESISTANCE COMBINATION THERAPY CREMOPHOR-FREE GENE DELIVERY PACLITAXEL TUMOR
ISSN号	0142-9612
通讯作者	tang,zh
中文摘要	there are two important obstacles for the currently applied anti-cancer drug delivery systems. one is the conflict between long-circulation and cellular uptake while the other one is the achievement of ideal anti-cancer efficacy. to solve these problems, we designed a polypeptide-based micelle system that combined the advantages of receptor mediated endocytosis and multi-drug delivery. firstly, an amphiphilic plg-g-ve/peg graft copolymer was prepared by grafting alpha-tocopherol (ve) and polyethylene glycol (peg) to poly(l-glutamic acid) (plc). then docetaxel (dtx) and cisplatin (cddp) were co-loaded into the plg-g-ve/peg micelles via hydrophobic and chelation effect. after that, the surface of the dual-drug-loaded micelles was decorated with an alpha(v)beta(3) integrin targeting peptide c(rgdfk). the targeted dual-drug-loaded micelles showed synergistic cytotoxicity and enhanced internalization rate in mouse melanoma (b16f1) cells. in vivo tests demonstrated that remarkable long circulation, anti-tumor and anti-metastasis efficacy could be achieved using this drug delivery system. this work revealed a strategy for the design and preparation of anti-cancer drug delivery systems with reduced side effect, enhanced anti-tumor and anti-metastasis efficacy. (c) 2013 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000332188900044
公开日期	2015-03-25
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50669]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Song, Wantong,Tang, Zhaohui,Zhang, Dawei,et al. Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin[J]. biomaterials,2014,35(9):3005-3014.
APA	Song, Wantong.,Tang, Zhaohui.,Zhang, Dawei.,Zhang,Ying.,Yu,Haiyang.,...&Chen,Xuesi.(2014).Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin.biomaterials,35(9),3005-3014.
MLA	Song, Wantong,et al."Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin".biomaterials 35.9(2014):3005-3014.