Multidrug resistance reversal agent from Jatropha elliptica

CORC > 西双版纳热带植物园 > 中国科学院西双版纳热带植物园 > 热带植物资源可持续利用重点实验室特色文献 > 小桐子相关文献

	Multidrug resistance reversal agent from Jatropha elliptica
	Marquez, B.
刊名	Phytochemistry
	2005
卷号	66 期号:15 页码:1804-1811
ISSN号	0031-9422
中文摘要	As part of an ongoing project to identify plant natural products as resistance-modifying agents, bioassay-guided fractionation of an extract of Jatropha elliptica (Pohl) Muell Arg. led to the isolation of a penta-substituted pyridine, namely 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (8). The structure was established by spectroscopic methods. This known compound was assayed for in vitro antibacterial and resistance-modifying activities against strains of Staphylococcus aureus possessing the MsrA and NorA resistance efflux mechanisms. Antibiotic efflux studies indicated that (8) acts as an inhibitor of the NorA efflux pump and restores the level of intracellular drug concentration. (c) 2005 Elsevier Ltd. All rights reserved.
公开日期	2015-01-28
内容类型	期刊论文
源URL	[http://ir.xtbg.org.cn/handle/353005/7321]
专题	西双版纳热带植物园_热带植物资源可持续利用重点实验室特色文献_小桐子相关文献
推荐引用方式 GB/T 7714	Marquez, B.. Multidrug resistance reversal agent from Jatropha elliptica[J]. Phytochemistry,2005,66(15):1804-1811.
APA	Marquez, B..(2005).Multidrug resistance reversal agent from Jatropha elliptica.Phytochemistry,66(15),1804-1811.
MLA	Marquez, B.."Multidrug resistance reversal agent from Jatropha elliptica".Phytochemistry 66.15(2005):1804-1811.