A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes

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	A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes
	Matsuse, I. T.
刊名	Journal of Ethnopharmacology
	1999
卷号	64 期号:1 页码:15-22
ISSN号	0378-8741
中文摘要	Aqueous and methanolic extracts of 39 Panamanian medicinal plants were tested for anti-human immunodeficiency virus (HIV) effects. The extracts were tested for the inhibition of HIV-induced cytopathic effects in cultured cells, HIV-reverse transcriptase (RT) and HIV-protease (PR) enzymes. The water extract of the branches of Jatropha curcas (Euphorbiaceae) inhibited strongly the HIV-induced cytopathic effects with low cytotoxicity. On the other hand, the water extracts of the whole plant of Chamaesyce hyssopifolia (Euphorbiaceae), the leaves of Cordia spinescens (Boraginaceae) and the aerial parts of Hyptis lantanifolia (Labiatae), and the methanol extract of the aerial parts of Tetrapteris macrocarpa (Malpighiaceae) were potent inhibitors of HIV-RT (IC50: 6-8 mu g/ml). Seven out of 39 plants were found to be moderate inhibitors of HIV-PR (IC50: 43-100 mu g/ml). Furthermore, we report on the respective inhibitory substances of J. curcas, C. hyssopifolia and C. spinescens, and their possible mechanism of action. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
语种	英语
公开日期	2015-01-28
内容类型	期刊论文
源URL	[http://ir.xtbg.org.cn/handle/353005/7044]
专题	西双版纳热带植物园_热带植物资源可持续利用重点实验室特色文献_小桐子相关文献
推荐引用方式 GB/T 7714	Matsuse, I. T.. A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes[J]. Journal of Ethnopharmacology,1999,64(1):15-22.
APA	Matsuse, I. T..(1999).A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes.Journal of Ethnopharmacology,64(1),15-22.
MLA	Matsuse, I. T.."A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes".Journal of Ethnopharmacology 64.1(1999):15-22.