Coordinating Expression of RNA Binding Proteins with Their mRNA Targets

CORC > 天津工业生物技术研究所 > 酵母基因组工程课题组江会锋 > 期刊论文

	Coordinating Expression of RNA Binding Proteins with Their mRNA Targets
	Jiang, Huifeng 1,2; Xu, Lin 2; Wang, Zhe 2; Keene, Jack 3; Gu, Zhenglong 2
刊名	SCIENTIFIC REPORTS
	2014-11-24
卷号	4 期号:7175
英文摘要	Post-transcriptional regulation by RNA binding proteins (RBPs) plays prominent roles in a variety of biological processes. In this study, by analyzing the global regulatory relationship between RBPs and their target mRNAs in yeast, we discovered that most RBP genes are co-regulated with their target genes, but the RBPs tend to dampen expression variation among their target mRNAs. We further examined a well-studied RBP gene, PUF3, and found that the protein decreases the variation of its target mRNAs by differentially affecting their decay. We also constructed a mathematical model to explain the relationship between RBPs and the expression of their target genes. Our results provided new insights into the functional importance of RBPs in coordinating the expression of their target genes.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	GENE-EXPRESSION ; REGULATORY NETWORK ; GENOME-WIDE ; YEAST ; MICRORNAS ; REGULONS ; NOISE ; TRANSCRIPTOME ; CANALIZATION ; BIOGENESIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000346184200004
公开日期	2015-01-24
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/311007/703]
专题	天津工业生物技术研究所_酵母基因组工程课题组江会锋_期刊论文
作者单位	1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China 2.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA 3.Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27701 USA
推荐引用方式 GB/T 7714	Jiang, Huifeng,Xu, Lin,Wang, Zhe,et al. Coordinating Expression of RNA Binding Proteins with Their mRNA Targets[J]. SCIENTIFIC REPORTS,2014,4(7175).
APA	Jiang, Huifeng,Xu, Lin,Wang, Zhe,Keene, Jack,&Gu, Zhenglong.(2014).Coordinating Expression of RNA Binding Proteins with Their mRNA Targets.SCIENTIFIC REPORTS,4(7175).
MLA	Jiang, Huifeng,et al."Coordinating Expression of RNA Binding Proteins with Their mRNA Targets".SCIENTIFIC REPORTS 4.7175(2014).