Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023

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	Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023
	[Bao, Jie ; Sun, Yu-Lin ; Zhang, Xiao-Yong ; Han, Zhuang ; He, Fei ; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China ; [Bao, Jie ; Sun, Yu-Lin ; Han, Zhuang] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China ; [Gao, Hai-Chun] Zhejiang Univ, Coll Life Sci, Hangzhou 310003, Zhejiang, Peoples R China ; [Qian, Pei-Yuan] Hong Kong Univ Sci & Technol, Dept Biol, Kln, Hong Kong, Peoples R China
刊名	JOURNAL OF ANTIBIOTICS
	2013
卷号	66 期号:4 页码:219-223
关键词	antifouling antibacterial gorgonian coral-associated fungus Penicillium sp. polyketide
ISSN号	0021-8820
通讯作者	shuhuaqi@scsio.ac.cn
中文摘要	Two new polyketides, 6,8,5'6'-tetrahydroxy-3'-methylflavone (1) and paecilin C (2), together with six known analogs secalonic acid D (3), secalonic acid B (4) penicillixanthone A (5), emodin (6), citreorosein (7) and isorhodoptilometrin (8) were obtained from a broth of gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023. Compounds 1 and 6-8 had significant antifouling activity against Balanus amphitrite larvae settlement with EC50 values of 6.7, 6.1, 17.9 and 13.7 mu gml(-1), respectively, and 3-5 showed medium antibacterial activity against four tested bacterial strains. This was the first report of antibacterial activity of 3-5 against marine bacteria and antifouling activity of 6-8 against marine biofouling organism's larvae. The results indicated that gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023 strain could produce antifouling and antibacterial compounds that might aid the host gorgonian coral in protection against marine pathogen bacteria, biofouling organisms and other intruders.
学科主题	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
资助信息	We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support.
原文出处	JAPAN ANTIBIOTICS RESEARCH ASSOC
语种	英语
WOS记录号	WOS:000318348100004
公开日期	2015-01-22
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/11043]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	[Bao, Jie,Sun, Yu-Lin,Zhang, Xiao-Yong,et al. Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023[J]. JOURNAL OF ANTIBIOTICS,2013,66(4):219-223.
APA	[Bao, Jie.,Sun, Yu-Lin.,Zhang, Xiao-Yong.,Han, Zhuang.,He, Fei.,...&[Qian, Pei-Yuan] Hong Kong Univ Sci & Technol, Dept Biol, Kln, Hong Kong, Peoples R China.(2013).Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023.JOURNAL OF ANTIBIOTICS,66(4),219-223.
MLA	[Bao, Jie,et al."Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023".JOURNAL OF ANTIBIOTICS 66.4(2013):219-223.