Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum

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	Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum
	[Sun, Yu-Lin ; Bao, Jie ; Zhang, Xiao-Yong ; He, Fei ; Nong, Xu-Hua ; Qi, Shu-Hua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Liu, Kai-Sheng ; Wang, Yi-Fei] Jinan Univ, Guangzhou, Guangdong, Peoples R China ; [Sun, Yu-Lin ; Bao, Jie ; Nong, Xu-Hua] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
刊名	PLANTA MEDICA
	2013
卷号	79 期号:15 页码:1474-1479
关键词	Penicillium oxalicum Trichocomaceae dihydrothiophene-condensed chromone cytotoxicity
ISSN号	0032-0943
通讯作者	shuhuaqi@scsio.ac.cn
中文摘要	Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, Penicillium oxalicum. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 and 2 were established by using the modified Mosher ester method and circular dichroism data of an in situ formed [Rh-2(OCOCF3)(4)] and [Mo-2(OAc)(4)] complex. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 mu M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 mu M, respectively. The structure-biological activity relationship of 1 was discussed.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助信息	This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B).
原文出处	GEORG THIEME VERLAG KG
语种	英语
WOS记录号	WOS:000330724200014
公开日期	2015-01-22
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10978]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	[Sun, Yu-Lin,Bao, Jie,Zhang, Xiao-Yong,et al. Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum[J]. PLANTA MEDICA,2013,79(15):1474-1479.
APA	[Sun, Yu-Lin.,Bao, Jie.,Zhang, Xiao-Yong.,He, Fei.,Nong, Xu-Hua.,...&Nong, Xu-Hua] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China.(2013).Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum.PLANTA MEDICA,79(15),1474-1479.
MLA	[Sun, Yu-Lin,et al."Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum".PLANTA MEDICA 79.15(2013):1474-1479.