Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

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	Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity
	He, LJ ; Liu, N ; Cheng, TL ; Chen, XJ ; Li, YD ; Shu, YS ; Qiu, ZL ; Zhang, XH
刊名	NATURE COMMUNICATIONS
	2014
卷号	5 期号:1 页码:5036-5036
关键词	PRIMARY VISUAL-CORTEX EXPERIENCE-DEPENDENT PLASTICITY CPG-BINDING PROTEIN-2 RETT-SYNDROME MOUSE MODEL RECEPTIVE-FIELDS CORTICAL PLASTICITY OCULAR DOMINANCE MUTANT MICE INTERNEURONS
ISSN号	2041-1723
通讯作者	Zhang, XH (reprint author), Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.,xhzhang@bnu.edu.cn
英文摘要	Mutations in the X-linked gene encoding the transcriptional modulator methyl-CpG-binding protein 2 (MeCP2) impair postnatal development of the brain. Here we use neuronal-type specific gene deletion in mice to show that conditional Mecp2 deletion in GABAergic parvalbumin-expressing (PV) cells (PV-Mecp2(-/y)) does not cause most Rett-syndrome-like behaviours, but completely abolishes experience-dependent critical period plasticity of primary visual cortex (V1) that develops normal visual functions. However, selective loss of Mecp2 in GABAergic somatostatin-expressing cells or glutamatergic pyramidal cells does not affect the critical period plasticity. MeCP2-deficient PV cells exhibit high intrinsic excitability, selectively reduced efficacy of recurrent excitatory synapses in V1 layer 4 circuits, and decreased evoked visual responses in vivo. Enhancing cortical gamma-aminobutyric acid (GABA) inhibition with diazepam infusion can restore critical period plasticity in both young and adult PV-Mecp2(-/y) mice. Thus, MeCP2 expression in inhibitory PV cells during the critical period is essential for local circuit functions underlying experience-dependent cortical plasticity.
学科主题	Multidisciplinary Sciences
收录类别	SCI
资助信息	973 Program [2011CBA00403, 2011CBA00400]; CAS SA-SIBS Scholarship Program
语种	英语
公开日期	2014-12-15
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2640]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	He, LJ,Liu, N,Cheng, TL,et al. Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity[J]. NATURE COMMUNICATIONS,2014,5(1):5036-5036.
APA	He, LJ.,Liu, N.,Cheng, TL.,Chen, XJ.,Li, YD.,...&Zhang, XH.(2014).Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity.NATURE COMMUNICATIONS,5(1),5036-5036.
MLA	He, LJ,et al."Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity".NATURE COMMUNICATIONS 5.1(2014):5036-5036.