| Properties and Inflammatory Effects of Various Size Fractions of Ambient Particulate Matter from Beijing on A549 and J774A.1 Cells | |
| Wang B. ; Li K. X. ; Jin W. J. ; Lu Y. ; Zhang Y. Z. ; Shen G. F. ; Wang R. ; Shen H. Z. ; Li W. ; Huang Y. ; Zhang Y. Y. ; Wang X. L. ; Li X. Q. ; Liu W. X. ; Cao H. Y. ; Tao S. | |
| 2013 | |
| 关键词 | air-pollution in-vitro coarse particles oxidative stress epithelial-cells oxide nanoparticles daily mortality surface-charge heavy-metals lung-cancer |
| 英文摘要 | Particulate matter (PM) is a major ambient air pollutant causing millions of premature deaths each year in China. The toxicity of PM is property and size dependent. In this study, ambient PM samples collected in Beijing were divided into five size fractions with nominal aerodynamic ranges of <0.40, 0.40-1.1, 1.1-3.3, 3.3-5.8, and 5.8-10 mu m. Individual size fractions were characterized for a number of properties including particle size distribution, specific surface area, zeta potential, dithiothreitol (DTT)-based redox ability, and contents of water-soluble organic carbon (WSOC), polycyclic aromatic hydrocarbons (PAHs), selected metals, and endotoxin. Human adenocarcinomic alveolar epithelial cell line A549 and small mouse monocyte-macrophage cell line J774A.1 were tested for their relative viabilities and inflammatory effects (interleukine-8 for A549 and tumor necrosis factor-a for J774A.1) after exposure to PM of various sizes. It was found that PM specific area was positively correlated with WSOC, high molecular weight PAHs, DTT-based redox ability, negatively correlated with surface zeta potential and lithophile metals. Several trace metals from combustion sources were enriched in intermediate size fractions. For both endotoxin concentrations of the PM and PM induced inflammatory cytokine expressions by the two cell lines, there were general increasing trends as PM size increased with an exception of the finest fraction, which induced the highest inflammatory effects. It seems that the size dependence of cytokine expression was associated with a number of properties including endotoxin content, zeta potential, settling velocity, metal content, and DTT-based redox ability. |
| 出处 | Environmental Science & Technology |
| 卷 | 47 |
| 期 | 18 |
| 页 | 10583-10590 |
| 收录类别 | SCI |
| 语种 | 英语 |
| ISSN号 | 0013-936X |
| 内容类型 | SCI/SSCI论文 |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/30218]  |
| 专题 | 地理科学与资源研究所_历年回溯文献 |
| 推荐引用方式 GB/T 7714 | Wang B.,Li K. X.,Jin W. J.,et al. Properties and Inflammatory Effects of Various Size Fractions of Ambient Particulate Matter from Beijing on A549 and J774A.1 Cells. 2013. |
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