Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment

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	Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment
	Liu GQ(刘国强)1,2 ; Liu ZL(刘志鲁)1 ; Li N(李娜)3; Wang XL(王晓龙)1 ; Zhou F(周峰)1 ; Liu WM(刘维民)1 ; Zhou F(周峰); Wang XL(王晓龙)
刊名	ACS Applied Materials and Interfaces
	2014
卷号	6 期号:22 页码:20452-20463
关键词	hairy microgels polyelectrolyte brushes hydration lubrication biomimetic synovial fluid arthritis treatment
ISSN号	1944-8244
通讯作者	王晓龙 ; 周峰
英文摘要	We report the fabrication of poly(3-sulfopropyl methacrylate potassium salt) (PSPMK) brushes grafted poly(N-isopropylacrylamide) (PNIPAAm) microgels and their potential as artificial synovial fluid for biomimetic aqueous lubrication and arthritis treatment. The negatively charged PSPMK brushes and thermosensitive PNIPAAm microgels play water-based hydration lubrication and temperature-triggered drug release, respectively. Under soft friction pairs, an ultralow coefficient of friction was achieved, while the hairy thermosensitive microgels showed a desirable temperature-triggered drugs release performance. Such a soft charged hairy microgel offers great possibility for designing intelligent synovial fluid. What is more, the combination of lubrication and drug loading capabilities enables the large clinical potential of novel soft hairy nanoparticles as synthetic joint lubricant fluid in arthritis treatment.
学科主题	材料科学与物理化学
收录类别	SCI
资助信息	NSFC (21125316;21303233;51335010;21434009);973 projects (2013CB632300);Key Research Program of CAS (KJZD-EW-M01)
语种	英语
WOS记录号	WOS:000345721400122
公开日期	2014-12-02
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/6843]
专题	兰州化学物理研究所_固体润滑国家重点实验室
通讯作者	Zhou F(周峰); Wang XL(王晓龙)
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu GQ,Liu ZL,Li N,et al. Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment[J]. ACS Applied Materials and Interfaces,2014,6(22):20452-20463.
APA	Liu GQ.,Liu ZL.,Li N.,Wang XL.,Zhou F.,...&王晓龙.(2014).Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment.ACS Applied Materials and Interfaces,6(22),20452-20463.
MLA	Liu GQ,et al."Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment".ACS Applied Materials and Interfaces 6.22(2014):20452-20463.