Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase

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	Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase
	Ji, CT ; Chen, Q ; Li, QL ; Huang, HB ; Song, YX ; Ma, JY ; Ju, JH
刊名	TETRAHEDRON LETTERS
	2014
卷号	55 期号:35 页码:4901-4904
关键词	Amide synthetase beta-Carboline McbA Chemoenzymatic synthesis
ISSN号	0040-4039
通讯作者	jju@scsio.ac.cn
中文摘要	McbA was characterized in vitro as a novel amide synthetase in the marinacarbolines A-D biosynthetic pathway, catalyzing amide bond formation between 1-acetyl-3-carboxy-beta-carboline (la) and substituted-beta-phenethylamines (1b, 213, 3b) and tryptamine (4b) in an ATP-dependent manner. Enzyme kinetic analyses highlight beta-phenethylamine as the most suitable amine donor. McbA showed broad substrate compatibility with substituted amines; 10 new beta-carboline analogues were chemoenzymatically generated. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Chemistry
收录类别	SCI
资助信息	MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606]
原文出处	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000340985800013
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10396]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Ji, CT,Chen, Q,Li, QL,et al. Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase[J]. TETRAHEDRON LETTERS,2014,55(35):4901-4904.
APA	Ji, CT.,Chen, Q.,Li, QL.,Huang, HB.,Song, YX.,...&Ju, JH.(2014).Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase.TETRAHEDRON LETTERS,55(35),4901-4904.
MLA	Ji, CT,et al."Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase".TETRAHEDRON LETTERS 55.35(2014):4901-4904.