Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 广东省海洋药物重点实验室

	Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis
	Chen, YL ; Zhang, WJ ; Zhu, YG ; Zhang, QB ; Tian, XP ; Zhang, S ; Zhang, CS
刊名	ORGANIC LETTERS
	2014
卷号	16 期号:3 页码:736-739
ISSN号	1523-7060
通讯作者	zhuyiguang2003@163.com ; czhang2006@gmail.com
中文摘要	The piericidin A1 (1) gene cluster was identified from the deep-sea derived Streptomyces sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4'-hydroxylase and PieB2 as a 4'-O-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in 1 biosynthesis. In addition, the shunt metabolite piericidin El (7) was identified as a novel analogue featuring a C-2/C-3 epoxy ring.
学科主题	Chemistry
收录类别	SCI
资助信息	MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
原文出处	AMER CHEMICAL SOC
WOS记录号	WOS:000331163900025
公开日期	2014-12-11
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10663]
专题	南海海洋研究所_广东省海洋药物重点实验室
推荐引用方式 GB/T 7714	Chen, YL,Zhang, WJ,Zhu, YG,et al. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis[J]. ORGANIC LETTERS,2014,16(3):736-739.
APA	Chen, YL.,Zhang, WJ.,Zhu, YG.,Zhang, QB.,Tian, XP.,...&Zhang, CS.(2014).Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis.ORGANIC LETTERS,16(3),736-739.
MLA	Chen, YL,et al."Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis".ORGANIC LETTERS 16.3(2014):736-739.