Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence

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	Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence
	Nan, Fangfang 1,3; Wu, Jie 1; Qi, Feng 1,3; Liu, Yan 1,3; Ngai, To 2; Ma, Guanghui 1
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2014-08-20
卷号	456 期号:8m 页码:246-252
关键词	Pickering emulsion Alginate Chitosan Uniform-sized Stimulus dependent
ISSN号	0927-7757
其他题名	Colloid Surf. A-Physicochem. Eng. Asp.
中文摘要	Owing to the absence of surfactants, Pickering emulsion shows little toxicity and emerges as an alternative for preparing potential carriers in biomedical area. Alginate particles are attractive stabilizers for this emulsion owing to their biocompatibility and pH sensitivity. However, their performance is still dissatisfactory due to the difficulty in preparing uniform submicron particles and the inappropriate hydrophilic property. In this study, we developed two strategies to circumvent above shortcomings. Uniform alginate particles with submicron to micron size were successfully prepared by premix membrane emulsification. In addition, the uniform particles were coated with relatively hydrophobic chitosan to overcome the high hydrophilicity of alginate particles. These uniform coated particles effectively stabilized the oil-in-water Pickering emulsion. It was found that the stability of emulsions was tremendously affected by particle size, and the least particle concentrations required for emulsion stability were proportional to the particle radii. Besides the particle size, the pH and salt concentration of aqueous phase was demonstrated to impact the stability of emulsions. The underlying mechanism was discussed in detail, concerning with three different-sized particles. Present work provided an effective strategy to prepare Pickering emulsion, which can be applied to design potent carriers in biomedical area. (C) 2014 Elsevier B.V. All rights reserved.
英文摘要	Owing to the absence of surfactants, Pickering emulsion shows little toxicity and emerges as an alternative for preparing potential carriers in biomedical area. Alginate particles are attractive stabilizers for this emulsion owing to their biocompatibility and pH sensitivity. However, their performance is still dissatisfactory due to the difficulty in preparing uniform submicron particles and the inappropriate hydrophilic property. In this study, we developed two strategies to circumvent above shortcomings. Uniform alginate particles with submicron to micron size were successfully prepared by premix membrane emulsification. In addition, the uniform particles were coated with relatively hydrophobic chitosan to overcome the high hydrophilicity of alginate particles. These uniform coated particles effectively stabilized the oil-in-water Pickering emulsion. It was found that the stability of emulsions was tremendously affected by particle size, and the least particle concentrations required for emulsion stability were proportional to the particle radii. Besides the particle size, the pH and salt concentration of aqueous phase was demonstrated to impact the stability of emulsions. The underlying mechanism was discussed in detail, concerning with three different-sized particles. Present work provided an effective strategy to prepare Pickering emulsion, which can be applied to design potent carriers in biomedical area. (C) 2014 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Physical
研究领域[WOS]	Chemistry
关键词[WOS]	MICROGEL PARTICLES ; DRUG-DELIVERY ; COLLOIDOSOMES ; NANOPARTICLES ; PH ; EMULSIFICATION ; MICROCAPSULES ; MICROSPHERES ; ACID
收录类别	SCI
原文出处	://WOS:000340318000032
语种	英语
WOS记录号	WOS:000340318000032
公开日期	2014-09-30
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/11500]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Nan, Fangfang,Wu, Jie,Qi, Feng,et al. Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2014,456(8m):246-252.
APA	Nan, Fangfang,Wu, Jie,Qi, Feng,Liu, Yan,Ngai, To,&Ma, Guanghui.(2014).Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,456(8m),246-252.
MLA	Nan, Fangfang,et al."Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 456.8m(2014):246-252.