Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases

	Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases
	Shen Aijin; Guo Zhimou; Liang Xinmiao
刊名	progress in chemistry
	2014
卷号	26 期号:1 页码:10-18
关键词	hydrophilic interaction liquid chromatography stationary phase polar drugs proteomics metabolomics
ISSN号	1005-281x
通讯作者	梁鑫淼
产权排序	待补充
合作状况	英
英文摘要	as an alternative high performance liquid chromatography technology, hydrophilic interaction liquid chromatography (hilic) plays an important role in the separation of highly polar and ionic compounds such as amino acids, carbohydrates, peptides and so on. the development of hilic stationary phases, which are considered as the core of chromatographic technology, is of great importance for the improvement of chromatographic separation selectivity and efficiency, influencing the application and generalization of hilic. to date, a great variety of commercial and academic hilic materials with abundant functional groups have been presented. according to the functional groups of chromatographic materials, the development of silica-based hilic stationary phases including unmodified silica, amino-based, cyano-based, diol-based, amide-based, poly (succinimide) -based, saccharides-based and zwitterion-based stationary phases are reviewed in the present article. meanwhile, the typical applications of hilic stationary phases in polar drugs separation, bioanalysis, proteomics, metabolomics, etc. are included. with increasing diversity of hilic materials, the selection of appropriate hilic stationary phase for the resolution of complex compounds becomes difficult. the development of systematic test samples and methods to access the separation selectivity is of great value for understanding the interaction mechanism of hilic stationary phases. thus, the investigation involving test samples to evaluate separation efficiencies and selectivities in hilic is also reviewed.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	monolithic capillary column ; tandem mass-spectrometry ; light-scattering detection ; mixed-mode ; polar compounds ; cation-exchange ; peptide separation ; charged solutes ; reversed-phase ; silica columns
收录类别	SCI
资助信息	1，1
原文出处	18
语种	英语
WOS记录号	WOS:000330554500002
公开日期	2014-09-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/119720]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Shen Aijin,Guo Zhimou,Liang Xinmiao. Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases[J]. progress in chemistry,2014,26(1):10-18.
APA	Shen Aijin,Guo Zhimou,&Liang Xinmiao.(2014).Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases.progress in chemistry,26(1),10-18.
MLA	Shen Aijin,et al."Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases".progress in chemistry 26.1(2014):10-18.