Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates

	Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates
	Chong, Qinglei; Xin, Xiaoyi; Wang, Chunxiang; Wu, Fan; Wan, Boshun
刊名	rsc advances
	2013
卷号	3 期号:44 页码:21222-21226
通讯作者	万伯顺
产权排序	待补充
合作状况	英
英文摘要	the michael addition and three-component cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates to form pyridones has been developed. aliphatic amines and aromatic amines could selectively be converted into n-alkyl-disubstituted 2-pyridones and n-aryl-trisubstituted 2-pyridones with good yields in the presence of wet ethanol, which means a suitable amount of water is required for this reaction. the michael addition and cyclization reaction process was confirmed through deuterium-labeling experiments, intermediates isolation and control experiments.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	ring-fused 2-pyridones ; regioselective synthesis ; pyridone alkaloids ; derivatives ; mechanism ; transformations ; cycloaddition ; hydrolysis ; scaffolds ; migration
收录类别	SCI
资助信息	1，1
原文出处	21226
语种	英语
WOS记录号	WOS:000326056600005
公开日期	2014-09-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/119481]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Chong, Qinglei,Xin, Xiaoyi,Wang, Chunxiang,et al. Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates[J]. rsc advances,2013,3(44):21222-21226.
APA	Chong, Qinglei,Xin, Xiaoyi,Wang, Chunxiang,Wu, Fan,&Wan, Boshun.(2013).Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates.rsc advances,3(44),21222-21226.
MLA	Chong, Qinglei,et al."Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates".rsc advances 3.44(2013):21222-21226.