JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization

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	JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization
	Deng, CY ; Lei, WL ; Xu, XH ; Ju, XC ; Liu, Y ; Luo, ZG
刊名	JOURNAL OF NEUROSCIENCE
	2014
卷号	34 期号:5 页码:1710-1723
关键词	KINESIN HEAVY-CHAIN AXONAL-TRANSPORT MEMBRANE TRAFFICKING HIPPOCAMPAL-NEURONS NEURITE OUTGROWTH CORTICAL-NEURONS MOTOR PROTEINS POLARITY COMPLEX JNK
ISSN号	0270-6474
通讯作者	Luo, ZG (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,zgluo@ion.ac.cn
英文摘要	Axon development and elongation require strictly controlled new membrane addition. Previously, we have shown the involvement of Rab10 in directional membrane insertion of plasmalemmal precursor vesicles (PPVs) during neuronal polarization and axonal growth. However, the mechanism responsible for PPV transportation remains unclear. Here we show that c-Jun N-terminal kinase-interacting protein 1 (JIP1) interacts with GTP-locked active form of Rab10 and directly connects Rab10 to kinesin-1 light chain (KLC). The kinesin-1/JIP1/Rab10 complex is required for anterograde transport of PPVs during axonal growth. Downregulation of JIP1 or KLC or disrupting the formation of this complex reduces anterograde transport of PPVs in developing axons and causes neuronal polarity defect. Furthermore, this complex plays an important role in neocortical neuronal polarization of rats in vivo. Thus, this study has demonstrated a mechanism underlying directional membrane trafficking involved in axon development.
学科主题	Neurosciences
收录类别	SCI
资助信息	National Natural Science Foundation of China [31330032, 31321091, 61327902]; Key State Research Program [2014CB910203]
语种	英语
公开日期	2014-07-30
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2626]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Deng, CY,Lei, WL,Xu, XH,et al. JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization[J]. JOURNAL OF NEUROSCIENCE,2014,34(5):1710-1723.
APA	Deng, CY,Lei, WL,Xu, XH,Ju, XC,Liu, Y,&Luo, ZG.(2014).JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization.JOURNAL OF NEUROSCIENCE,34(5),1710-1723.
MLA	Deng, CY,et al."JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization".JOURNAL OF NEUROSCIENCE 34.5(2014):1710-1723.