Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan

	Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan
	Qin, Yukun 1; Liu, Song 1; Xing, Ronge1 ; Li, Kecheng 1,2; Yu, Huahua1 ; Li, Pengcheng1
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2013-10-01
卷号	61 页码:58-62
关键词	Chitosan 1 Click reaction Characterization Antifungal activity 2 3-Triazole
ISSN号	0141-8130
通讯作者	Xing, RG
中文摘要	With an aim to discover novel chitosan derivatives with significant activities against crop-threatening fungi, (1,2,3-triazol-4-yl)methyl nicotinate chitosan (TAMNCS) was prepared via azide-alkyne click reaction. Its structure was characterized by FT-IR, H-1 NMR, elemental analysis, DSC, and SEM. In vitro antifungal properties of TAMNCS against Rhizoctonia solani Kuhn (R. solani), Stemphylium solani weber (S. solani), and Alternaria porri (A. porri) were studied at the concentrations ranged from 0.25 mg/mL to 1.0 mg/mL. Experiments conducted displayed the derivative had obviously enhanced antifungal activity after chemical modification compared with original chitosan. Moreover, it was shown that TAMNCS can 94.2% inhibit growth of A. pouf at 1.0 mg/mL, while dose at which the fungicide triadimefon had lower inhibitory index (62.2%). The primary antifungal results described here indicate this derivative may be a promising candidate as an antifungal agent. (C). 2013 Elsevier B.V. All rights reserved.
英文摘要	With an aim to discover novel chitosan derivatives with significant activities against crop-threatening fungi, (1,2,3-triazol-4-yl)methyl nicotinate chitosan (TAMNCS) was prepared via azide-alkyne click reaction. Its structure was characterized by FT-IR, H-1 NMR, elemental analysis, DSC, and SEM. In vitro antifungal properties of TAMNCS against Rhizoctonia solani Kuhn (R. solani), Stemphylium solani weber (S. solani), and Alternaria porri (A. porri) were studied at the concentrations ranged from 0.25 mg/mL to 1.0 mg/mL. Experiments conducted displayed the derivative had obviously enhanced antifungal activity after chemical modification compared with original chitosan. Moreover, it was shown that TAMNCS can 94.2% inhibit growth of A. pouf at 1.0 mg/mL, while dose at which the fungicide triadimefon had lower inhibitory index (62.2%). The primary antifungal results described here indicate this derivative may be a promising candidate as an antifungal agent. (C). 2013 Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	CLICK CHEMISTRY ; CARBOXYMETHYL CHITOSAN ; THIOUREA DERIVATIVES ; CHITIN
收录类别	SCI
原文出处	10.1016/j.ijbiomac.2013.05.023
语种	英语
WOS记录号	WOS:000326660700009
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16724]
专题	海洋研究所_海洋生物技术研发中心海洋研究所_海洋环境工程技术研究发展中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Qin, Yukun,Liu, Song,Xing, Ronge,et al. Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2013,61:58-62.
APA	Qin, Yukun,Liu, Song,Xing, Ronge,Li, Kecheng,Yu, Huahua,&Li, Pengcheng.(2013).Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,61,58-62.
MLA	Qin, Yukun,et al."Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 61(2013):58-62.