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	Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132
	Liu, Dong1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Wang, Bin-Gui1; Wang, BG
刊名	HELVETICA CHIMICA ACTA
	2013-06-01
卷号	96期号:6页码:1055-1061
关键词	Aspergillus niger MA-132 Avicennia marina Fungi Nigerasterols A and B Antiproliferative activity
ISSN号	0018-019X
通讯作者	Wang, BG
中文摘要	Two new 6,8(14),22-hexadehydro-5,9-epidioxy-3,15-dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9-epidioxy-sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay.
英文摘要	Two new 6,8(14),22-hexadehydro-5,9-epidioxy-3,15-dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9-epidioxy-sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay.
学科主题	Chemistry
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	PENICILLIUM-CHRYSOGENUM QEN-24S ; EDIBLE MUSHROOMS ; CHAETOMIUM-GLOBOSUM ; MARINE ; DERIVATIVES ; ANTIFUNGAL ; METABOLITE ; SPONGE ; ASSAY
收录类别	SCI ; IC
原文出处	10.1002/hlca.201200332
语种	英语
WOS记录号	WOS:000320611900006
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16609]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, BG
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Dong,Li, Xiao-Ming,Li, Chun-Shun,et al. Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132[J]. HELVETICA CHIMICA ACTA,2013,96(6):1055-1061.
APA	Liu, Dong,Li, Xiao-Ming,Li, Chun-Shun,Wang, Bin-Gui,&Wang, BG.(2013).Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132.HELVETICA CHIMICA ACTA,96(6),1055-1061.
MLA	Liu, Dong,et al."Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132".HELVETICA CHIMICA ACTA 96.6(2013):1055-1061.

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