Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity
	Zhao, Dan-Dan 1; Zhao, Qin-Shi2 ; Liu, Li1,2 ; Chen, Zhong-Qin 1; Zeng, Wei-Min 1; Lei, Hong 1; Zhang, Yan-Long 1
刊名	MOLECULES
	2014-03-01
卷号	19 期号:3 页码:3345-3355
关键词	Dryopteris fragrans (L.) Schott compounds MTT cytotoxic activity
ISSN号	1420-3049
通讯作者	Zhang,YL (reprint author),Heilongjiang Univ,Coll Life Sci,Key Lab Mol Biol Heilongjiang Prov,Harbin 150080,Peoples R China. ; zhaodandan@hlju.edu.cn ; qinshizhao@mail.kib.ac.cn ; liliuhlju@gmail.com ; zqchenhd@163.com ; wmzenghd@163.com ; hleihd@163.com ; YLZhangHd@163.com
英文摘要	One new coumarin, dryofracoumarin A (1), and eight known compounds 2-9 were isolated from Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound 1 was determined to be 8-hydroxyl-4-isopropyl-7-methyl-6-methyl-2H-benzopyran-2-one. Two dimers, trans-and cis-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl] cyclohex-1-ene (compounds 8 and 9), were isolated from the Dryopteris genus for the first time. The other six were esculetin (2), isoscopoletin (3), methylphlorbutyrophenone (4), aspidinol (5), albicanol (6) and (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-ol (7). All compounds were evaluated for their cytotoxic effects by the MTT assay. Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Their IC50 values ranged between 2.73 +/- 0.86 +/- mu M and 24.14 +/- 3.12 mu M. These active compounds might be promising lead compounds for the treatment of cancer.
学科主题	Chemistry
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	ANTITUMOR-PROMOTING ACTIVITY ; REFRACTORY PROSTATE-CANCER ; TARGETED THERAPY ; BREAST-CANCER ; AERIAL PARTS ; DERIVATIVES ; SEPARATION ; GLYCOSIDE ; LEAVES
收录类别	SCI
资助信息	Natural Science Foundation Project, Heilongjiang Province, China [D201023]; Science Research Project of Educational Commission, Heilongjiang Province, China [11551384]; International Scientific and Technological Cooperation Project of Heilongjiang Province, China [WB08B08]
语种	英语
WOS记录号	WOS:000335826800040
公开日期	2014-06-23
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18115]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Heilongjiang Univ, Coll Life Sci, Key Lab Mol Biol Heilongjiang Prov, Harbin 150080, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Dan-Dan,Zhao, Qin-Shi,Liu, Li,et al. Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity[J]. MOLECULES,2014,19(3):3345-3355.
APA	Zhao, Dan-Dan.,Zhao, Qin-Shi.,Liu, Li.,Chen, Zhong-Qin.,Zeng, Wei-Min.,...&Zhang, Yan-Long.(2014).Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity.MOLECULES,19(3),3345-3355.
MLA	Zhao, Dan-Dan,et al."Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity".MOLECULES 19.3(2014):3345-3355.