Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism

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	Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism
	Tian, Liting ; Zheng, Guang ; Sommar, Johan Nilsson ; Liang, Yihuai ; Lundh, Tomas ; Broberg, Karin ; Lei, Lijian ; Guo, Weijun ; Li, Yulan ; Tan, Mingguang ; Skerfving, Staffan ; Jin, Taiyi ; Bergdahl, Ingvar A.
刊名	TOXICOLOGY LETTERS
	2013
卷号	221 期号:2 页码:CONCATENATE(Sheet1!I194,-Sheet1!J194)
ISSN号	0378-4274
英文摘要	Blood lead concentration (B-Pb), the main biomarker of lead exposure and risk, is curvi-linearily related to exposure. We assessed plasma lead (P-Pb) as a marker for both lead exposure and toxic effects. We examined claims that delta-aminolevulinic acid dehydratase genotype (ALAD) can modify lead toxicity. In 290 lead-exposed and 91 unexposed Chinese workers, we determined P-Pb, B-Pb, urinary lead (U-Pb), AMD polymorphism (rs1800435, ALAD112; TaqMan assay), and also toxic effects on heme synthesis (blood zinc protoporphyrin and hemoglobin, urinary delta-aminolevulic acid), on the kidneys (urinary albumin, beta(2)microglobulin and N-acetyl-beta-D-glucosaminidase) and on the peripheral nervous system (sensory and motor conduction velocities).In exposed workers, median P-Pb was 4.10 (range 0.35-27) mu g/L, B-Pb 401 (110-950) mu g/L, and U-Pb 188 (22-590) mu g/g creatinine. P-Pb had a higher ratio between exposed and unexposed workers (median 39, range 18-110) than B-Pb (19, 15-36; p<0.001) and U-Pb (28, 15-36; p<0.001). All three biomarkers were associated with all toxic effects (P-Pb: r(s)= -0.10 to 0.79; B-Pb: r(s) = -0.08 to 0.75; all p <0.05). In the exposed workers, B-Pb and U-Pb were significantly higher (p = 0.04) in AIAD2 carriers (7% in the exposed population) than in ALAD1 homozygotes. P-Pb values were similar; ALAD1 homozygotes suffered higher kidney toxicity at the same P-Pb.Conclusions: (i) P-Pb has advantages over B-Pb as a biomarker of high Pb exposure, but it was not significantly better as an index of risk of toxicity. (ii) The ALAD genotype modifies toxicokinetics and toxicodynamics. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000323087000004
公开日期	2014-06-13
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/13806]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Tian, Liting,Zheng, Guang,Sommar, Johan Nilsson,et al. Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism[J]. TOXICOLOGY LETTERS,2013,221(2):CONCATENATE(Sheet1!I194,-Sheet1!J194).
APA	Tian, Liting.,Zheng, Guang.,Sommar, Johan Nilsson.,Liang, Yihuai.,Lundh, Tomas.,...&Bergdahl, Ingvar A..(2013).Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism.TOXICOLOGY LETTERS,221(2),CONCATENATE(Sheet1!I194,-Sheet1!J194).
MLA	Tian, Liting,et al."Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism".TOXICOLOGY LETTERS 221.2(2013):CONCATENATE(Sheet1!I194,-Sheet1!J194).