kappa-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	kappa-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice
	Wang, Jing ; Yu, Shouyi ; Jiao, Shouhai ; Lv, Xiaowen ; Ma, Min ; Du, Yuguo
刊名	FOOD AND CHEMICAL TOXICOLOGY
	2013
卷号	59 期号:0 页码:303-310
通讯作者	Wang, J
中文摘要	Microcystins (MCs) are a family of cyclic heptapeptides that are produced by blooming algae Microcystis. MCs have been implicated in the development of liver cancer, necrosis and even intrahepatic bleeding. Effective prophylactic approaches and complete removal of MCs are urgently needed. Accumulating evidence suggests that microcystin-LR (MC-LR)-induced damage is accompanied by oxidative stress. Supplementation of Se can enhance resistance to oxidative stress. Therefore, in the present study, we investigated the protective effects of kappa-Selenocarrageenan (Se-Car), a kind of organic Se compound, in Balb/c mice exposed to MC-LR. Our results proved that Se-Car could significantly ameliorate the hepatic damage induced by MC-LR, including serum markers of liver dysfunction, oxidative damages and histological alterations. Furthermore, Se-Car could significantly alleviate the up-regulation of the molecular targets indicating mitochondrial dysfunction and endoplasmic reticulum stress induced by MC-LR. In conclusion, Se-Car showed clear protection against toxicity induced by MC-LR. Thus, Se-Car could be useful as a new category of anti-MC-LR toxicity reagent. (c) 2013 Elsevier Ltd. All rights reserved.
收录类别	SCI
WOS记录号	WOS:000324280000039
公开日期	2014-06-06
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7476]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wang, Jing,Yu, Shouyi,Jiao, Shouhai,et al. kappa-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,59(0):303-310.
APA	Wang, Jing,Yu, Shouyi,Jiao, Shouhai,Lv, Xiaowen,Ma, Min,&Du, Yuguo.(2013).kappa-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice.FOOD AND CHEMICAL TOXICOLOGY,59(0),303-310.
MLA	Wang, Jing,et al."kappa-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice".FOOD AND CHEMICAL TOXICOLOGY 59.0(2013):303-310.