Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus

	Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus
	Zhang, Shengting 1; Zhao, Yang 1,2,3; Hu, Xiaofeng 1; Liu, Zongyun 1,2,3; Chen, Xiaocheng 4; Chen, Xuequn 1,2,3; Du, Jizeng 1,2,3
刊名	molecular and cellular endocrinology
	2013-08-25
卷号	376 期号:1-2 页码:33-42
关键词	Microtus oeconomus Mouse Hypoxia Insulin-like growth factor mRNA stability U-rich element
ISSN号	0303-7207
通讯作者	chen, xq (reprint author), zhejiang univ, sch med, dept basic med sci, div neurobiol & physiol, res bldg c-507,zhejiang campus,866 yuhangtang rd, hangzhou 310058, zhejiang, peoples r china.
中文摘要	our previous study revealed the particular expression patterns of insulin-like growth factor 1 (igf1) and insulin-like growth factor binding protein 1 (igfbp1) in the qinghai-tibet plateau root vole (microtus oeconomus) under hypoxic challenge. here we report the molecular mechanisms of igf gene regulation associated with adaptation to hypoxia. m. oeconomus igf1 and igfbp1 were shown to be highly conserved. hypoxia (8.0% o-2, 6 h) did not change the liver-derived le expression in either m. oeconomus or mouse. hypoxia significantly upregulated hepatic igfbp1 gene expression and igfbp1 levels in the liver and plasma of the mouse, but not in m. oeconomus. a functional u-rich element in the 3' untranslated region was found in mouse igfbp1 mrna, which was associated with igfbp1 mrna stabilization and upregulation under hypoxia, and this u-rich element was eliminated in the m. oeconomus igfbp1, resulting in blunted igfbp1 mrna upregulation, which might be understood as a sequence variation modified during molecular evolution under hypoxia. (c) 2013 published by elsevier ireland ltd.
英文摘要	our previous study revealed the particular expression patterns of insulin-like growth factor 1 (igf1) and insulin-like growth factor binding protein 1 (igfbp1) in the qinghai-tibet plateau root vole (microtus oeconomus) under hypoxic challenge. here we report the molecular mechanisms of igf gene regulation associated with adaptation to hypoxia. m. oeconomus igf1 and igfbp1 were shown to be highly conserved. hypoxia (8.0% o-2, 6 h) did not change the liver-derived le expression in either m. oeconomus or mouse. hypoxia significantly upregulated hepatic igfbp1 gene expression and igfbp1 levels in the liver and plasma of the mouse, but not in m. oeconomus. a functional u-rich element in the 3' untranslated region was found in mouse igfbp1 mrna, which was associated with igfbp1 mrna stabilization and upregulation under hypoxia, and this u-rich element was eliminated in the m. oeconomus igfbp1, resulting in blunted igfbp1 mrna upregulation, which might be understood as a sequence variation modified during molecular evolution under hypoxia. (c) 2013 published by elsevier ireland ltd.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	cell biology ; endocrinology & metabolism
研究领域[WOS]	cell biology ; endocrinology & metabolism
关键词[WOS]	factor-binding protein-1 ; growth-factor-i ; hepatic tissue oxygenation ; messenger-rna stability ; graded hypoxia ; cell-migration ; fetal hypoxia ; hepg2 cells ; expression ; stabilization
收录类别	SCI
语种	英语
WOS记录号	WOS:000323095100004
公开日期	2014-05-09
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/3931]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Zhejiang Univ, Sch Med, Dept Basic Med Sci, Div Neurobiol & Physiol, Hangzhou 310058, Zhejiang, Peoples R China 2.Zhejiang Univ, Minist Hlth, Key Lab Med Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China 3.Zhejiang Univ, Zhejiang Prov Key Lab Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China 4.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining 810001, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shengting,Zhao, Yang,Hu, Xiaofeng,et al. Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus[J]. molecular and cellular endocrinology,2013,376(1-2):33-42.
APA	Zhang, Shengting.,Zhao, Yang.,Hu, Xiaofeng.,Liu, Zongyun.,Chen, Xiaocheng.,...&Du, Jizeng.(2013).Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus.molecular and cellular endocrinology,376(1-2),33-42.
MLA	Zhang, Shengting,et al."Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus".molecular and cellular endocrinology 376.1-2(2013):33-42.