Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 资源植物与生物技术所级重点实验室

	Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431
	Yang, Yanfang 1; Zhao, Hainan 2; Barrero, Roberto A.3; Zhang, Baohong 4; Sun, Guiling5,6 ; Wilson, Iain W.7; Xie, Fuliang 4; Walker, Kevin D.8,9; Parks, Joshua W.10; Bruce, Robert 10
刊名	BMC GENOMICS
	2014-01-25
卷号	15 期号:1
关键词	Penicillium aurantiogriseum NRRL 62431 Paclitaxel Taxol (TM) Endophytic fungi Genome sequence Horizontal gene transfer
英文摘要	Background: Paclitaxel (Taxol (TM)) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae, an endophytic fungus of T. brevifolia. Subsequently, paclitaxel was found in hazel (Corylus avellana L.) and in several other endophytic fungi. The distribution of paclitaxel in plants and endophytic fungi and the reported sequence homology of key genes in paclitaxel biosynthesis between plant and fungi species raises the question about whether the origin of this pathway in these two physically associated groups could have been facilitated by horizontal gene transfer.
类目[WOS]	Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]	Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]	TAXUS-BREVIFOLIA ; TAXOL BIOSYNTHESIS ; NATURAL-PRODUCT ; PACIFIC YEW ; OVERPRODUCTION ; ANTICANCER ; DIVERSITY ; EVOLUTION ; TAXANES ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000332573300001
公开日期	2014-04-19
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18035]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位	1.Chinese Acad Forestry, State Key Lab Tree Genet & Breeding, Res Inst Forestry, Beijing 100091, Peoples R China 2.China Agr Univ, Coll Agr Biotechnol, Beijing 100094, Peoples R China 3.Murdoch Univ, Ctr Comparat Genom, Perth, WA 6150, Australia 4.E Carolina Univ, Dept Biol, Greenville, NC 27858 USA 5.Southwest Forestry Univ, Sch Life Sci, Kunming 650224, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China 7.CSIRO Plant Ind, Canberra, ACT 2001, Australia 8.Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA 9.Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA 10.Univ Portland, Dept Chem, Portland, OR 97203 USA
推荐引用方式 GB/T 7714	Yang, Yanfang,Zhao, Hainan,Barrero, Roberto A.,et al. Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431[J]. BMC GENOMICS,2014,15(1).
APA	Yang, Yanfang.,Zhao, Hainan.,Barrero, Roberto A..,Zhang, Baohong.,Sun, Guiling.,...&Hoffman, Angela.(2014).Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431.BMC GENOMICS,15(1).
MLA	Yang, Yanfang,et al."Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431".BMC GENOMICS 15.1(2014).