Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging

	Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging
	Liu FY ; He XX ; Liu L ; You HP ; Zhang HM ; Wang ZX
刊名	biomaterials
	2013
卷号	34 期号:21 页码:5218-5225
关键词	RAY COMPUTED-TOMOGRAPHY UP-CONVERSION NANOPARTICLES COATED GOLD NANOPARTICLES IN-VIVO SURFACE MODIFICATION NANOPROBES LUMINESCENCE FLUORESCENT THERAPY SPHERES
ISSN号	0142-9612
通讯作者	wang zx
中文摘要	here, we report the covalently conjugation of lanthanide doped nagdf4:yb3+, er3+@nagdf4 upconverting nanoparticles (ucnps) on methylphosphonate functionalized silica nanospheres (psi nps) for in vivo upconversion luminescence (ucl), t-1-weighted magnetic resonance (mr), and x-ray computed tomography (ct) multi-modality imaging. the nanocomposites (psi@ucnps) were synthesized by a facile ligand exchange strategy. the hydrophobic psi@ucnps were transferred into aqueous solution by surface coating pluronic f127. the pluronic f127 coated psi@ucnps (psi@ucnps@f127) exhibit excellent stability in biological medium, inappreciable cytotoxicity and negligible organ toxicity. the psi@ucnps@f127 also shows brighter ucl, and higher ct/mr enhancements than that of pluronic f127 coated nagdf4:yb3+, er3+@nagdf4 ucnp. in detail, the capability of psi@ucnp5@f127 as high performance contrast agents for in vivo multi-modality (ucl/mr/ct) imaging is evaluated successfully through small-animal experiments. (c) 2013 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000319630000031
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49771]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu FY,He XX,Liu L,et al. Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging[J]. biomaterials,2013,34(21):5218-5225.
APA	Liu FY,He XX,Liu L,You HP,Zhang HM,&Wang ZX.(2013).Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging.biomaterials,34(21),5218-5225.
MLA	Liu FY,et al."Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging".biomaterials 34.21(2013):5218-5225.