Development of Polymeric Nanoprobes with Improved Lifetime Dynamic Range and Stability for Intracellular Oxygen Sensing

	Development of Polymeric Nanoprobes with Improved Lifetime Dynamic Range and Stability for Intracellular Oxygen Sensing
	Liu H ; Yang H ; Hao X ; Xu HJ ; Lv Y ; Xiao DB ; Wang HD ; Tian ZY
刊名	small
	2013
卷号	9 期号:15 页码:2639-2648
关键词	OPTICAL CHEMICAL SENSORS BRAIN-TUMOR DELINEATION MOLECULAR-OXYGEN DISSOLVED-OXYGEN PEBBLE SENSORS LIVE CELLS SOL-GEL LIVING CELLS IN-VIVO NANOSENSORS
ISSN号	1613-6810
通讯作者	xiao db
中文摘要	a class of core-shell nanoparticles possessing a layer of biocompatible shell and hydrophobic core with embedded oxygen-sensitive platinum-porphyrin (pttfpp) dyes is developed via a radical-initiated microemulsion co-polymerization strategy. the influences of host matrices and the pttfpp incorporation manner on the photophysical properties and the oxygen-sensing performance of the nanoparticles are investigated. self-loading capability with cells and intracellular-oxygen-sensing ability of the as-prepared nanoparticle probes in the range 0%-20% oxygen concentration are confirmed. polymeric nanoparticles with optimized formats are characterized by their relatively small diameter (<50 nm), core-shell structures with biocompatible shells, covalent-attachment-imparted leak-free construction, improved lifetime dynamic range (up to 44 s), excellent storage stability and photostability, and facile cell uptake. the nanoparticles' small sensor diameter and core-shell structure with biocompatible shell make them suitable for intracellular detection applications. for intracellular detection applications, the leak-free feature of the as-prepared nanoparticle sensor effectively minimizes potential chemical interferences and cytotoxicity. as a salient feature, improved lifetime dynamic range of the sensor is expected to enable precise oxygen detection and control in specific practical applications in stem-cell biology and medical research. such a feature-packed nanoparticle oxygen sensor may find applications in precise oxygen-level mapping of living cells and tissue.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000327792600021
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49681]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu H,Yang H,Hao X,et al. Development of Polymeric Nanoprobes with Improved Lifetime Dynamic Range and Stability for Intracellular Oxygen Sensing[J]. small,2013,9(15):2639-2648.
APA	Liu H.,Yang H.,Hao X.,Xu HJ.,Lv Y.,...&Tian ZY.(2013).Development of Polymeric Nanoprobes with Improved Lifetime Dynamic Range and Stability for Intracellular Oxygen Sensing.small,9(15),2639-2648.
MLA	Liu H,et al."Development of Polymeric Nanoprobes with Improved Lifetime Dynamic Range and Stability for Intracellular Oxygen Sensing".small 9.15(2013):2639-2648.