Poly(ester amide) blend microspheres for oral insulin delivery

	Poly(ester amide) blend microspheres for oral insulin delivery
	He P ; Liu HY ; Tang ZH ; Deng MX ; Yang Y ; Pang X ; Chen XS
刊名	international journal of pharmaceutics
	2013
卷号	455 期号:41641 页码:259-266
关键词	POLYMERIC MICROPARTICLES INTESTINAL-ABSORPTION PROTEIN DRUGS DIABETIC-RATS NANOPARTICLES BIOAVAILABILITY MACROMOLECULES HYDROGELS PEPTIDES CHITOSAN
ISSN号	0378-5173
通讯作者	tang zh
中文摘要	this study developed a novel oral insulin formulation centered on microspheres consisting of a blend of biodegradable poly(ester amide) (pea). in the formulation, l-lysine-/l-leucine-based pea with pendant cooh groups (pea-cooh) was used as a ph-responsive material for the protection of insulin from the harsh environmental conditions of the stomach. arginine-based pea (arg-pea) was introduced to improve the intestinal absorption of the drug. the influence of both the hydrophobicity of pea-cooh and the content of arg-pea was investigated in detail on microsphere surface morphology, drug loading, and the in vitro release profile of insulin. the pea-cooh/arg-pea blend microspheres protected the loaded insulin in simulated gastric fluid and released insulin in a fast and sustained manner in simulated intestinal fluid. the in vivo test demonstrated that the oral administration of insulin-loaded pea blend microspheres could effectively suppress the blood glucose level in diabetic rats for 10h, and the oral bioavailability was improved to 5.89 + 1.84% in healthy rats. these results indicate that the pea blend microspheres are promising vehicles for the oral delivery of insulin. (c) 2013 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000324522100030
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49539]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	He P,Liu HY,Tang ZH,et al. Poly(ester amide) blend microspheres for oral insulin delivery[J]. international journal of pharmaceutics,2013,455(41641):259-266.
APA	He P.,Liu HY.,Tang ZH.,Deng MX.,Yang Y.,...&Chen XS.(2013).Poly(ester amide) blend microspheres for oral insulin delivery.international journal of pharmaceutics,455(41641),259-266.
MLA	He P,et al."Poly(ester amide) blend microspheres for oral insulin delivery".international journal of pharmaceutics 455.41641(2013):259-266.