Differentiation of glucose-containing disaccharides isomers by fragmentation of the deprotonated non-covalent dimers using negative electrospray ionization tandem mass spectrometry

	Differentiation of glucose-containing disaccharides isomers by fragmentation of the deprotonated non-covalent dimers using negative electrospray ionization tandem mass spectrometry
	Wan DB ; Yang HM ; Yan CY ; Song FR ; Liu ZQ ; Liu SY
刊名	talanta
	2013
卷号	115 页码:870-875
关键词	ANOMERIC CONFIGURATION LINKAGE POSITION ION OLIGOSACCHARIDES GLYCOPROTEIN ATTACHMENT ANION
ISSN号	0039-9140
通讯作者	liu sy
中文摘要	in this work, the glucose-containing disaccharide isomers were studied using negative electrospray ionization tandem mass spectrometry (esi-ms/ms). interestingly, the full-scan mass spectra of the disaccharides revealed that the deprotonated dimers were the predominant gas phase ions during ionization process. importantly, several diagnostic fragment ions relative to linkage positions and anomeric configurations, arising from the covalent bond dissociation of dimers without breakdown of the non-covalent complexes, can be detected in the tandem mass spectra. based on the scarce fragmentation characteristic, an original and simple approach for structural discrimination of disaccharide isomers was put forward. in addition, density functional theory (dft) was employed to find out the reason why several fragmentations of intramolecular sugar bonds had preceded breakdown of the noncovalent complexes. crown copyright (c) 2013 published by elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000328095600124
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49537]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wan DB,Yang HM,Yan CY,et al. Differentiation of glucose-containing disaccharides isomers by fragmentation of the deprotonated non-covalent dimers using negative electrospray ionization tandem mass spectrometry[J]. talanta,2013,115:870-875.
APA	Wan DB,Yang HM,Yan CY,Song FR,Liu ZQ,&Liu SY.(2013).Differentiation of glucose-containing disaccharides isomers by fragmentation of the deprotonated non-covalent dimers using negative electrospray ionization tandem mass spectrometry.talanta,115,870-875.
MLA	Wan DB,et al."Differentiation of glucose-containing disaccharides isomers by fragmentation of the deprotonated non-covalent dimers using negative electrospray ionization tandem mass spectrometry".talanta 115(2013):870-875.