Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells
	Liu, Zi 1,3; Ma, Liang 1; Wen, Zhe-Sheng 2; Cheng, Yong-Xian 4; Zhou, Guang-Biao 1
刊名	ACS MEDICINAL CHEMISTRY LETTERS
	2014-02-01
卷号	5 期号:2 页码:113-118
关键词	Ethoxysanguinarine CIP2A lung cancer cell proliferation apoptosis
ISSN号	1948-5875
通讯作者	Zhou,GB (reprint author),Chinese Acad Sci,Inst Zool,Div Mol Carcinogenesis & Targeted Therapy Canc,State Key Lab Biomembrane & Membrane Biotechnol,Beijing 100101,Peoples R China. ; gbzhou@ioz.ac.cn
英文摘要	Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that is able to stabilize c-Myc oncogenic transcription factor and promote proliferation and transformation of cells. CIP2A is overexpressed in many primary tumors, and pharmacological inactivation of CIP2A is an emerging concept for the development of novel anticancer agents. In this study, we demonstrate that overexpression of CIP2A predicts poor prognosis in lung cancer, and a natural compound, ethoxysanguinarine (ESG), effectively down-regulates CIP2A protein and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. ESG inhibits proliferation and induces apoptosis of lung cancer cells, and enhances the effects of cisplatin on malignant cells. Taken together, our findings demonstrate that CIP2A is inversely associated with the clinical outcome of lung cancer, and ESG can serve as a lead compound for the development of CIP2A inhibitor for cancer therapies.
学科主题	Chemistry, Medicinal
类目[WOS]	Chemistry, Medicinal
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	HEPATOCELLULAR-CARCINOMA ; INDUCED APOPTOSIS ; PROGNOSTIC ROLE ; EXPRESSION ; PP2A ; TRANSFORMATION ; SANGUINARINE ; BORTEZOMIB ; RESISTANCE ; CISPLATIN
收录类别	SCI
资助信息	National Key Program for Basic Research [2012CB910800, 2010CB529201]; National Natural Science Foundation [81071930, 81171925, 81201577]; Special Foundation of President; Strategic Leading Science & Technology Programme of the Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000331493600003
公开日期	2014-04-09
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17924]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Zool, Div Mol Carcinogenesis & Targeted Therapy Canc, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China 2.Sun Yat Sen Univ, Canc Hosp, Dept Thorac Surg, Guangzhou 510080, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,et al. Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells[J]. ACS MEDICINAL CHEMISTRY LETTERS,2014,5(2):113-118.
APA	Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,Cheng, Yong-Xian,&Zhou, Guang-Biao.(2014).Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.ACS MEDICINAL CHEMISTRY LETTERS,5(2),113-118.
MLA	Liu, Zi,et al."Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells".ACS MEDICINAL CHEMISTRY LETTERS 5.2(2014):113-118.