Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 中国科学院东亚植物多样性与生物地理学重点实验室

	Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo
	Yu, Song Yi 1; Lee, Ik-Soo 1; Jung, Seung-Hyun 1; Lee, Yun Mi 1; Lee, Yu-Ri 1; Kim, Joo-Hwan 2; Sun, Hang3 ; Kim, Jin Sook 1
刊名	PLANTA MEDICA
	2013-12-01
卷号	79 期号:18 页码:1705-1709
关键词	Brandisia hancei Scrophulariaceae phenylpropanoid glycoside advanced glycation end-product rat lens aldose reductase zebrafish diabetic vascular complications
ISSN号	0032-0943
通讯作者	Kim,JS (reprint author),Korea Inst Oriental Med,KM Based Herbal Drug Dev Grp,Herbal Med Res Div,Taejon 305811,South Korea.
英文摘要	In our continuing efforts to identify effective naturally sourced agents for diabetic complications, five caffeoylated phenylpropanoid glycosides, acteoside (1), isoacteoside (2), poliumoside (3), brandioside (4), and pheliposide (5) were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-5) were subjected to an in vitro bioassay evaluating their inhibitory activity on advanced glycation end product formation and rat lens aldose reductase activity. All tested compounds exhibited significant inhibition of advanced glycation end product formationwith IC50 values of 4.6-25.7 mu M, compared with those of aminoguanidine (IC50 = 1056 mu M) and quercetin (IC50 = 28.4 mu M) as positive controls. In the rat lens aldose reductase assay, acteoside, isoacteoside, and poliumoside exhibited greater inhibitory effects on rat lens aldose reductase with IC50 values of 0.83, 0.83, and 0.85 mu M, respectively, than those of the positive controls, 3,3-tetramethyleneglutaric acid (IC50= 4.03 mu M) and quercetin (IC50 = 7.2 mu M). In addition, the ef-fect of acteoside on the dilation of hyaloid-retinal vessels induced by high glucose in larval zebrafish was investigated. Acteoside reduced the diameters of high glucose-induced hyaloid-retinal vessels by 69% at 10 mu Mand 81% at 20 mu M, compared to the high glucose-treated control group. These results suggest that B. hancei and its active components might be beneficial in the treatment and prevention of diabetic vascular complications.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	PROTEIN GLYCATION ; STRUCTURAL REQUIREMENTS ; DIABETIC COMPLICATIONS ; MEDICINAL-PLANTS ; CATARACTOGENESIS ; PURIFICATION ; FLAVONOIDS ; SEEDS ; ACID ; AGES
收录类别	SCI
资助信息	Korea Institute of Oriental Medicine [K12040, K13040]
语种	英语
WOS记录号	WOS:000328696600003
公开日期	2014-03-06
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17512]
专题	昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室
作者单位	1.Korea Inst Oriental Med, KM Based Herbal Drug Dev Grp, Herbal Med Res Div, Taejon 305811, South Korea 2.Kyungwon Univ, Dept Life Sci, Songnam, South Korea 3.Chinese Acad Sci, Kunming Inst Bot, Lab Biodivers & Biogeog, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yu, Song Yi,Lee, Ik-Soo,Jung, Seung-Hyun,et al. Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo[J]. PLANTA MEDICA,2013,79(18):1705-1709.
APA	Yu, Song Yi.,Lee, Ik-Soo.,Jung, Seung-Hyun.,Lee, Yun Mi.,Lee, Yu-Ri.,...&Kim, Jin Sook.(2013).Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo.PLANTA MEDICA,79(18),1705-1709.
MLA	Yu, Song Yi,et al."Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo".PLANTA MEDICA 79.18(2013):1705-1709.