Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages

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	Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages
	He XC; Qu ZG; Xu F; Lin M; Wang JL(王九令); Shi XH(施兴华); Lu TJ
刊名	SOFT MATTER
	2014-01-07
通讯作者邮箱	zgqu@mail.xjtu.edu.cn
卷号	10 期号:1 页码:139-148
ISSN号	1744-683X
通讯作者	Qu, ZG (reprint author), Xi An Jiao Tong Univ, Minist Educ, Sch Energy & Power Engn, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
产权排序	[He, XiaoCong; Qu, ZhiGuo] Xi An Jiao Tong Univ, Minist Educ, Sch Energy & Power Engn, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China; [He, XiaoCong; Qu, ZhiGuo; Xu, Feng; Lin, Min; Lu, TianJian] Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China; [Xu, Feng; Lin, Min] Xi An Jiao Tong Univ, Minist Educ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China; [Wang, JiuLing; Shi, XingHua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
中文摘要	Studying dendrimer-biomembrane interactions is important for understanding drug and gene delivery. In this study, coarse-grained molecular dynamics simulations were performed to investigate the behaviors of polyamidoamine (PAMAM) dendrimers (G4 and G5) as they interacted with asymmetric membranes from different sides of the bilayer, thus mimicking different dendrimer transport stages. The G4 dendrimer could insert into the membrane during an equilibrated state, and the G5 dendrimer could induce pore formation in the membrane when the dendrimers interacted with the outer side (outer interactions) of an asymmetric membrane [with 10% dipalmitoyl phosphatidylserine (DPPS) in the inner leaflet of the membrane]. During the interaction with the inner side of the asymmetric membrane (inner interactions), the G4 and G5 dendrimers only adsorbed onto the membrane. As the membrane asymmetry increased (e.g., increased DPPS percentage in the inner leaflet of the membrane), the G4 and G5 dendrimers penetrated deeper into the membrane during the outer interactions and the G4 and G5 dendrimers were adsorbed more tightly onto the membrane for the inner interactions. When the DPPS content reached 50%, the G4 dendrimer could completely penetrate through the membrane from the outer side to the inner side. Our study provides molecular understanding and reference information about different dendrimer transport stages during drug and gene delivery.
学科主题	交叉与边缘领域的力学
分类号	一类
收录类别	SCI ; EI
资助信息	National Natural Science Foundation of China [51322604, 11272327, 11372243]; National 111 Project of China [B06024]; Major International Joint Research Program of China [11120101002]; Key Project of Chinese Ministry of Education [313045]; South Wisdom Valley Innovative Research Team Program; International Science & Technology Cooperation Program of China [2013DFG02930]; China Young 1000-Talent Program; Program for New Century Excellent Talents in University [NCET-12-0437]
原文出处	http://dx.doi.org/10.1039/c3sm51990b
语种	英语
WOS记录号	WOS:000327849000016
公开日期	2014-02-13
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/48082]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	He XC,Qu ZG,Xu F,et al. Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages[J]. SOFT MATTER,2014,10(1):139-148.
APA	He XC.,Qu ZG.,Xu F.,Lin M.,Wang JL.,...&Lu TJ.(2014).Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages.SOFT MATTER,10(1),139-148.
MLA	He XC,et al."Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages".SOFT MATTER 10.1(2014):139-148.