In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass

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	In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass
	Li, HF ; Xie, XH ; Zhao, K ; Wang, YB ; Zheng, YF ; Wang, WH ; Qin, L
刊名	ACTA BIOMATERIALIA
	2013
卷号	9 期号:10 页码:8561
关键词	Ca20Mg20Zn20Sr20Yb20 alloy High-entropy alloys Bulk metallic glasses Biodegradable metals Bone
ISSN号	1742-7061
通讯作者	Zheng, YF (reprint author), Peking Univ, State Key Lab Turbulence & Complex Syst, Beijing 100871, Peoples R China.
中文摘要	In order to enhance the corrosion resistance of the Ca65Mg15Zn20 bulk metallic glass, which has too fast a degradation rate for biomedical applications, we fabricated the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass because of the unique properties of high-entropy alloys. Our results showed that the mechanical properties and corrosion behavior were enhanced. The in vitro tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass could stimulate the proliferation and differentiation of cultured osteoblasts. The in vivo animal tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass did not show any obvious degradation after 4 weeks of implantation, and they can promote osteogenesis and new bone formation after 2 weeks of implantation. The improved mechanical properties and corrosion behavior can be attributed to the different chemical composition as well as the formation of a unique high-entropy atomic structure with a maximum degree of disorder. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
资助信息	National. Basic Research Program of China (973 Program) [2012CB619102]; National Science Fund for Distinguished Young Scholars [51225101]; National Natural Science Foundation of China [31170909]; Research Fund for the Doctoral Program of Higher Education [20100001110011]; Natural Science Foundation of Heilongjiang Province [ZD201012]; Guangdong Province innovation RD team project [201001C0104669453]
语种	英语
公开日期	2014-01-16
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/57105]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Li, HF,Xie, XH,Zhao, K,et al. In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass[J]. ACTA BIOMATERIALIA,2013,9(10):8561.
APA	Li, HF.,Xie, XH.,Zhao, K.,Wang, YB.,Zheng, YF.,...&Qin, L.(2013).In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass.ACTA BIOMATERIALIA,9(10),8561.
MLA	Li, HF,et al."In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass".ACTA BIOMATERIALIA 9.10(2013):8561.