Protein structural codes and nucleation sites for protein folding

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	Protein structural codes and nucleation sites for protein folding
	Jiang, F ; Li, N
刊名	CHINESE PHYSICS
	2007
卷号	16 期号:2 页码:392
关键词	SECONDARY STRUCTURE INTERNAL-FRICTION HELIX DIPOLE AMINO-ACIDS DESIGN PREDICTION DATABASE STABILIZATION PEPTIDES DYNAMICS
ISSN号	1009-1963
通讯作者	Jiang, F (reprint author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100080, Peoples R China.
中文摘要	One of the long-standing controversial arguments in protein folding is Levinthal's paradox. We have recently proposed a new nucleation hypothesis and shown that the nucleation residues are the most conserved sequences in protein. To avoid the complicated effect of tertiary interactions, we limit our search for structural codes to the nucleation residues. Starting with the hypotheses of secondary structure nucleation and conservation of residues important for folding, we have analysed 762 folds classified as unique by SCOP. Segments of 17 residues around the top 20% conserved amino acids are analysed, resulting in approximately 100 clusters each for the main secondary structure classes of helix, sheet and coil. Helical clusters have the longest correlation range, coils the shortest (four residues). Strong specific sequence-structure correlation is observed for coil but not for helix and sheet, suggesting a mapping relationship between the sequence and the structure for coil. We propose that the central sequences in these clusters form structural codes', a useful basis set for identifying nucleation sites, protein fragments stable in isolation, and secondary structural patterns in proteins (particularly turns and loops).
收录类别	SCI
语种	英语
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/51557]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Jiang, F,Li, N. Protein structural codes and nucleation sites for protein folding[J]. CHINESE PHYSICS,2007,16(2):392.
APA	Jiang, F,&Li, N.(2007).Protein structural codes and nucleation sites for protein folding.CHINESE PHYSICS,16(2),392.
MLA	Jiang, F,et al."Protein structural codes and nucleation sites for protein folding".CHINESE PHYSICS 16.2(2007):392.