Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro

CORC > 物理研究所 > 物理所公开发表论文 > 期刊论文

	Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro
	Sun, Z ; Liu, Z ; Meng, J ; Meng, J ; Duan, JH ; Xie, SS ; Lu, X ; Zhu, ZH ; Wang, C ; Chen, SC ; Xu, HY ; Yang, XD
刊名	PLOS ONE
	2011
卷号	6 期号:6
关键词	NF-KAPPA-B OXIDATIVE STRESS PROTEIN ENHANCE MAMMALIAN-CELLS GENE DELIVERY PLASMID DNA MICE TRANSPORTERS TOXICITY BIODISTRIBUTION
ISSN号	1932-6203
通讯作者	Sun, Z: Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China.
中文摘要	With the expansion of the potential applications of carbon nanotubes (CNT) in biomedical fields, the toxicity and biocompatibility of CNT have become issues of growing concern. Since the immune system often mediates tissue damage during pathogenesis, it is important to explore whether CNT can trigger cytotoxicity through affecting the immune functions. In the current study, we evaluated the influence of CNT on the cytotoxicity mediated by human lymphocytes in vitro. The results showed that while CNT at low concentrations (0.001 to 0.1 mu g/ml) did not cause obvious cell death or apoptosis directly, it enhanced lymphocyte-mediated cytotoxicity against multiple human cell lines. In addition, CNT increased the secretion of IFN-gamma and TNF-alpha by the lymphocytes. CNT also upregulated the NF-kappa B expression in lymphocytes, and the blockage of the NF-kappa B pathway reduced the lymphocyte-mediated cytotoxicity triggered by CNT. These results suggest that CNT at lower concentrations may prospectively initiate an indirect cytotoxicity through affecting the function of lymphocytes.
收录类别	SCI
资助信息	Ministry of Science and Technology of China [2011CB933504, 2011CB911003, 2011CB911004]; Natural Science Foundation of China [81071870]
语种	英语
公开日期	2013-09-17
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/34478]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Sun, Z,Liu, Z,Meng, J,et al. Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro[J]. PLOS ONE,2011,6(6).
APA	Sun, Z.,Liu, Z.,Meng, J.,Meng, J.,Duan, JH.,...&Yang, XD.(2011).Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro.PLOS ONE,6(6).
MLA	Sun, Z,et al."Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro".PLOS ONE 6.6(2011).