A model for biased diffusion of collagenase along collagen fibrils

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	A model for biased diffusion of collagenase along collagen fibrils
	Qian, J ; Xie, P ; Dou, SX ; Wang, PY
刊名	JOURNAL OF THEORETICAL BIOLOGY
	2006
卷号	243 期号:3 页码:322
关键词	FLUORESCENCE CORRELATION SPECTROSCOPY MATRIX METALLOPROTEINASES FIBROBLAST COLLAGENASE MOLECULAR MOTORS CATABOLISM MOVEMENT PEPTIDE RATCHET PROTEIN
ISSN号	0022-5193
通讯作者	Xie, P: Chinese Acad Sci, Inst Phys, Lab Soft Matter Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100080, Peoples R China.
中文摘要	We present a model to describe the biased diffusion of a collagenase along collagen fibrils. Based on the structures of collagen fibril and collagenase, the interaction is described by a one-dimensional potential that is symmetric in the region of no cleavage and asymmetric in the cleavage region. We show that the mean velocity of the unidirectional diffusion of the collagenase depends on the three parameters: the asymmetric ratio of the local potential in the cleavage region, the chemical reaction rate of proteolysis and the jumping rate of collagenase between two neighboring tracks. We calculate the correlation function and the mean transport velocity for both wild-type and mutant collagenases along collagen fibrils, the results of which are consistent with the previous experiments. (c) 2006 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
公开日期	2013-09-17
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/32985]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Qian, J,Xie, P,Dou, SX,et al. A model for biased diffusion of collagenase along collagen fibrils[J]. JOURNAL OF THEORETICAL BIOLOGY,2006,243(3):322.
APA	Qian, J,Xie, P,Dou, SX,&Wang, PY.(2006).A model for biased diffusion of collagenase along collagen fibrils.JOURNAL OF THEORETICAL BIOLOGY,243(3),322.
MLA	Qian, J,et al."A model for biased diffusion of collagenase along collagen fibrils".JOURNAL OF THEORETICAL BIOLOGY 243.3(2006):322.