Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta
	Gao, Xue-Mei 1,2,3; Niu, De-Yun 1,2; Meng, Chun-Yang 1,2; Yao, Fu-Quan 1,2; Zhou, Bin 1,2; Wang, Rui-Rui 4; Yang, Liu-Meng 4; Zheng, Yong-Tang 4; Hu, Qiu-Fen 1,2; Sun, Han-Dong3
刊名	JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
	2013-12-01
卷号	24 期号:12 页码:2021-+
关键词	Schisandra neglecta dibenzocyclooctadiene lignans anti-HIV-1 activities cytotoxicities
ISSN号	0103-5053
通讯作者	Hu,QF (reprint author),Yunnan Univ Nationalities,State Ethn Affairs Commiss,Key Lab Ethn Med Resource Chem,Kunming 650031,Peoples R China. ; huqiufena@aliyun.com ; xwl@mail.kib.ac.cn
英文摘要	Four new dibenzocyclooctadiene lignans, neglectalignans A-D (1-4), together with nineteen known compounds (5-23) were isolated from the stems of Schisandra neglecta. Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques. Compounds 1-4 were evaluated for their anti-HIV activities and cytotoxicities. The results revealed that compounds 1-4 showed moderate anti-HIV-1 activities with therapeutic index (TI) values above 61.7, 22.6, 57.7, and 27.9, respectively, and weak cytotoxic activities for some selected cell lines.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	SCHIZANDRA-CHINENSIS BAILL ; ANTI-HIV-1 ACTIVITIES ; CONSTITUENTS ; GOMISIN ; WILSONIANA ; FRUITS
收录类别	SCI ; IC
资助信息	NSFYP [2012FB178]; Excellent Scientific and Technological Team of Yunnan High School [2010CI08]; Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team [2011HC008]; Open Research Fund Program of Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities) [2010XY08]
语种	英语
WOS记录号	WOS:000328703200017
公开日期	2014-01-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17451]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China 2.Minist Educ, Kunming 650031, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China
推荐引用方式 GB/T 7714	Gao, Xue-Mei,Niu, De-Yun,Meng, Chun-Yang,et al. Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2013,24(12):2021-+.
APA	Gao, Xue-Mei.,Niu, De-Yun.,Meng, Chun-Yang.,Yao, Fu-Quan.,Zhou, Bin.,...&Xiao, Wei-Lie.(2013).Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,24(12),2021-+.
MLA	Gao, Xue-Mei,et al."Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 24.12(2013):2021-+.