8-9 ' linked neolignans with cytotoxicity from Alpinia conchigera

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	8-9 ' linked neolignans with cytotoxicity from Alpinia conchigera
	Xu, Jun-Ju 1,2; Zeng, Guang-Zhi 3; Yang, Sheng-Chao 1; Shen, Yong 1; Tan, Ning-Hua 3
刊名	FITOTERAPIA
	2013-12-01
卷号	91 页码:82-86
关键词	Zingiberaceae Alpinia conchigera Neolignans Conchigeranals A-E Cytotoxicity
ISSN号	0367-326X
通讯作者	Shen,Y (reprint author),Yunnan Agr Univ,Yunnan Res Ctr Good Agr Practice Dominant Chinese,Kunming 650201,Peoples R China.,pharmsy@sina.com ; nhtan@mail.kib.ac.cn
英文摘要	Five new 8-9' linked neolignans conchigeranals A-E (1-5), together with three known compounds galanganal (6), galanganols A (7) and B (8), were isolated from the whole plant of Alpinia conchigera. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1-8 were tested against two cancer cell lines A549 and Hela. Results showed that 4, 5, 7 and 8 exhibited cytotoxicity against A549 with the IC50 values of 1236, 9.72, 10.26, 13.05 mu g/ml, respectively, and 1-8 against Hela with the IC50 values from 1.53 to 5.29 mu g/ml. (C) 2013 Published by Elsevier B.V.
学科主题	Pharmacology & Pharmacy
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	NITRIC-OXIDE PRODUCTION ; ABSOLUTE STEREOSTRUCTURES ; INHIBITORY-ACTIVITY ; SESQUITERPENES ; OXYPHYLLA ; DIARYLHEPTANOIDS ; BLEPHAROCALYX ; DITERPENOIDS ; RHIZOMES ; GALANGA
收录类别	SCI
资助信息	National Natural Science Foundation of China [31000159, 31360080]
语种	英语
WOS记录号	WOS:000327574300012
公开日期	2014-01-13
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17413]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Agr Univ, Yunnan Res Ctr Good Agr Practice Dominant Chinese, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jun-Ju,Zeng, Guang-Zhi,Yang, Sheng-Chao,et al. 8-9 ' linked neolignans with cytotoxicity from Alpinia conchigera[J]. FITOTERAPIA,2013,91:82-86.
APA	Xu, Jun-Ju,Zeng, Guang-Zhi,Yang, Sheng-Chao,Shen, Yong,&Tan, Ning-Hua.(2013).8-9 ' linked neolignans with cytotoxicity from Alpinia conchigera.FITOTERAPIA,91,82-86.
MLA	Xu, Jun-Ju,et al."8-9 ' linked neolignans with cytotoxicity from Alpinia conchigera".FITOTERAPIA 91(2013):82-86.